Publications by authors named "Williams Hinojosa"
Background And Objective: Patients with pulmonary hypertension (PH) may present with hypoxaemia at rest or during daily activities. There is no epidemiological data on the prescription of long-term oxygen therapy (LTOT) in patients with PH. The study sought to analyse the prevalence and incidence of LTOT prescription among patients with pulmonary arterial hypertension (PAH) or chronic thromboembolic pulmonary hypertension (CTEPH) in Spain and to determine predictors for this prescription.
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- This study explored the long-term effects of triple therapy with prostanoids on patients suffering from pulmonary arterial hypertension related to congenital heart disease, as there is limited research on its safety and efficacy.
- A retrospective analysis involved 60 patients, showing significant improvements in walking distance, functional class, and NT-proBNP levels after two years of treatment, with mild side effects reported in a third of the participants.
- The findings suggest that triple therapy is both safe and effective, particularly benefiting those without Eisenmenger syndrome and those with specific heart defects.
Introduction And Objectives: The management of persistent moderate-severe tricuspid regurgitation (TR) in patients with chronic thromboembolic pulmonary hypertension after treatment with pulmonary endarterectomy (PEA) or balloon pulmonary angioplasty (BPA) is not well defined. This study aimed to analyze the progression and predictors of significant persistent postintervention TR and its prognostic impact.
Methods: This single-center observational study included 72 patients undergoing PEA and 20 who completed a BPA program with a previous diagnosis of chronic thromboembolic pulmonary hypertension and moderate-to-severe TR.
Article Synopsis
- Advanced age and related health issues often prevent older patients with chronic thromboembolic pulmonary hypertension (CTEPH) from undergoing pulmonary endarterectomy, making balloon pulmonary angioplasty (BPA) a promising alternative, albeit with limited existing data on its safety and effectiveness for this age group.
- A study involving 33 patients aged 70 and above who underwent BPA showed significant improvements in health metrics, including reduced pulmonary arterial pressure and enhanced cardiac function, along with a favorable safety profile.
- The results indicated that BPA is not only safe but also effective in reducing symptoms and medication needs, with only a small percentage of procedures leading to serious complications.
The coronavirus 2019 disease (COVID-19) pandemic threatened the Spanish health-care system. Patients with demanding conditions such as precapillary pulmonary hypertension (PH) faced a potentially severe infection, while their usual access to medical care was restricted. This prospective, unicentric study assessed the impact of COVID-19 on PH patients' outcomes and the operational changes in the PH network.
View Article and Find Full Text PDFHypotension is the main finding in patients admitted to an intensive care unit (ICU) with the diagnosis of septic shock and it is related to worse outcomes. In these patients, several underlying causes of hypotension may co-exist, including vasoplegia, hypovolemia, drug-mediated venodilation, or myocardial dysfunction. Nowadays, echocardiography has been positioned as an essential tool in any ICU set to assess fluid status, ventricular ejection fraction, or any other myocardial complications.
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- A study was conducted to compare the complications of using peripherally inserted central catheters (PICC) and tunneled central catheters (Hickman) in patients with pulmonary hypertension (PH) receiving continuous epoprostenol treatment over a period from January 2010 to July 2020.
- The research involved 109 patients and analyzed 175 catheter placements, finding no significant difference in infection rates between PICC and Hickman catheters, but PICC catheters had a notably higher rate of mechanical complications such as catheter occlusion and venous thrombosis.
- Despite the mechanical complications leading to more hospitalizations for patients with PICC, there was no significant
Background And Aims: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the sole causative agent of coronavirus infectious disease-19 (COVID-19).
Methods And Results: We performed a retrospective single-center study of consecutively admitted patients between March 1st and May 15th 2020, with a definitive diagnosis of SARS-CoV-2 infection. The primary end-point was to evaluate the association of lipid markers with 30-days all-cause mortality in COVID-19.
Introduction: Coronavirus disease 2019 (COVID-19) is a systemic disease characterized by a disproportionate inflammatory response in the acute phase. This study sought to identify clinical sequelae and their potential mechanism.
Methods: We conducted a prospective single-center study (NCT04689490) of previously hospitalized COVID-19 patients with and without dyspnea during mid-term follow-up.
Introduction And Objectives: To determine whether renin-angiotensin system inhibitor (RASi) prescription is associated with better outcomes after transcatheter aortic valve implantation (TAVI) and surgical aortic valve replacement (SAVR).
Methods: All comparative studies of RASi vs no RASi prescription in patients undergoing TAVI/SAVR were gathered from PubMed, Web of Science, and Google Scholar through August, 2019. We extracted hazard ratios (HRs) with their confidence intervals (CIs) for mortality from each study and combined study-specific estimates using inverse variance-weighted averages of logarithmic HRs in the random effects model.