Mitigating Cardiotoxicity Associated with Anticancer Drugs: An Updated Systematic Review.

Introduction: This systematic review investigated strategies to mitigate cardiotoxicity induced by anticancer medications, emphasizing exercise and pharmacological interventions.

Methods: We systematically reviewed three randomized controlled trials, one ATOPE trial, and one retrospective cohort study.

Results: Among 448 patients, exercise interventions, particularly in breast cancer patients, demonstrated significant improvements in left ventricular ejection fraction (LVEF) and cardiotoxicity prevention.