Publications by authors named "William Z Bowie"
Article Synopsis
- Xenograft models simulate human tumor biology, allowing researchers to manipulate the tumor microenvironment and examine drug responses.
- Spatially resolved transcriptomics (SRT) is a technique that helps analyze the spatial organization of these models but lacks specialized processing pipelines.
- Xenomake is a new standalone pipeline designed to automate the handling of spatial xenograft reads, improving data processing, alignment, and analysis while ensuring biological relevance.
Xenograft models are attractive models that mimic human tumor biology and permit one to perturb the tumor microenvironment and study its drug response. Spatially resolved transcriptomics (SRT) provide a powerful way to study the organization of xenograft models, but currently there is a lack of specialized pipeline for processing xenograft reads originated from SRT experiments. Xenomake is a standalone pipeline for the automated handling of spatial xenograft reads.
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