Publications by authors named "William Yarosh"
Article Synopsis
- Defensins are antimicrobial peptides in mammals divided into three subfamilies: alpha, beta, and theta, each with different structural features and sources.
- Each defensin shows anti-HIV-1 activity but works through different mechanisms: RTD-1 (theta) inhibits HIV-1 entry, while HNP-1 (alpha) and HBD-2 (beta) prevent its replication, even if introduced after infection.
- All three types also downmodulate the CXCR4 receptor and have varying effects on different strains of HIV-1, with findings indicating that their actions could influence previous conclusions in research.
