From genome to phenome: Predicting multiple cancer phenotypes based on somatic genomic alterations via the genomic impact transformer.

Cancers are mainly caused by somatic genomic alterations (SGAs) that perturb cellular signaling systems and eventually activate oncogenic processes. Therefore, understanding the functional impact of SGAs is a fundamental task in cancer biology and precision oncology. Here, we present a deep neural network model with encoder-decoder architecture, referred to as genomic impact transformer (GIT), to infer the functional impact of SGAs on cellular signaling systems through modeling the statistical relationships between SGA events and differentially expressed genes (DEGs) in tumors.

Automatic Human-like Mining and Constructing Reliable Genetic Association Database with Deep Reinforcement Learning.

The increasing amount of scientific literature in biological and biomedical science research has created a challenge in continuous and reliable curation of the latest knowledge discovered, and automatic biomedical text-mining has been one of the answers to this challenge. In this paper, we aim to further improve the reliability of biomedical text-mining by training the system to directly simulate the human behaviors such as querying the PubMed, selecting articles from queried results, and reading selected articles for knowledge. We take advantage of the efficiency of biomedical text-mining, the exibility of deep reinforcement learning, and the massive amount of knowledge collected in UMLS into an integrative artificial intelligent reader that can automatically identify the authentic articles and effectively acquire the knowledge conveyed in the articles.

Structured Correspondence Topic Models for Mining Captioned Figures in Biological Literature.

A major source of information (often the most crucial and informative part) in scholarly articles from scientific journals, proceedings and books are the figures that directly provide images and other graphical illustrations of key experimental results and other scientific contents. In biological articles, a typical figure often comprises multiple panels, accompanied by either scoped or global captioned text. Moreover, the text in the caption contains important semantic entities such as protein names, gene ontology, tissues labels, etc.

Information Extraction as Link Prediction: Using Curated Citation Networks to Improve Gene Detection.

In this paper we explore the usefulness of various types of publication-related metadata, such as citation networks and curated databases, for the task of identifying genes in academic biomedical publications. Specifically, we examine whether knowing something about which genes an author has previously written about, combined with information about previous coauthors and citations, can help us predict which new genes the author is likely to write about in the future. Framed in this way, the problem becomes one of predicting links between authors and genes in the publication network.

A stacked graphical model for associating sub-images with sub-captions.

There is extensive interest in mining data from full text. We have built a system called SLIF (for Subcellular Location Image Finder), which extracts information on one particular aspect of biology from a combination of text and images in journal articles. Associating the information from the text and image requires matching sub-figures with the sentences in the text.

A graph-search framework for associating gene identifiers with documents.

Background: One step in the model organism database curation process is to find, for each article, the identifier of every gene discussed in the article. We consider a relaxation of this problem suitable for semi-automated systems, in which each article is associated with a ranked list of possible gene identifiers, and experimentally compare methods for solving this geneId ranking problem. In addition to baseline approaches based on combining named entity recognition (NER) systems with a "soft dictionary" of gene synonyms, we evaluate a graph-based method which combines the outputs of multiple NER systems, as well as other sources of information, and a learning method for reranking the output of the graph-based method.

High-recall protein entity recognition using a dictionary.

Summary: Protein name extraction is an important step in mining biological literature. We describe two new methods for this task: semiCRFs and dictionary HMMs. SemiCRFs are a recently-proposed extension to conditional random fields (CRFs) that enables more effective use of dictionary information as features.