Real-Time Analysis of Oxygen Gradient in Oocyte Respiration Using a High-Density Microelectrode Array.

Physiological events related to oxygen concentration gradients provide valuable information to determine the state of metabolizing biological cells. The existing oxygen sensing methods (i.e.

An Integrated Biosensor System With a High-Density Microelectrode Array for Real-Time Electrochemical Imaging.

Electrochemical methods have been shown to be advantageous to life sciences by supporting studies and discoveries in metabolism activities, DNA analysis, and neurotransmitter signaling. Meanwhile, the integration of Microelectrode Array (MEA) and the accessibility of CMOS technology permit high-density electrochemical sensing method. This paper describes an electrochemical imaging system equipped with a custom CMOS microchip.

Electrochemical biosensor system using a CMOS microelectrode array provides high spatially and temporally resolved images.

The ability to view biological events in real time has contributed significantly to research in the life sciences. While video capture of real time changes in anatomical relationships is important, it is equally important to visualize real time changes in the chemical communications that drive cell behaviors. This paper describes an electrochemical imaging system capable of capturing changes in chemical gradients in live tissue slices.