Publications by authors named "William Selove"
Background: Allogeneic stem cell transplant (allo-SCT) is a mainstay of treatment for acute myeloid leukemia (AML). Its success depends largely on response of donor T lymphocytes against leukemia cells, known as graft-vs-leukemia (GvL) effect. A key potential driver of GvL is immune response to mutation-derived neoantigens.
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- The study developed the Clonal Hematopoiesis Risk Score (CHRS) to assess the risk of clonal hematopoiesis (CH) in healthy individuals, but recognized that most CH cases are diagnosed when symptoms appear.
- Researchers examined clinical data from 94 CH patients, distinguishing between those with only DNMT3A/TET2/ASXL1 mutations ('sole DTA') and those with additional mutations ('non-sole DTA').
- Results revealed that TET2 was the most common mutation, sole DTA patients rarely progressed to myeloid neoplasm (MN), while non-sole DTA patients had a significant progression rate, especially if they had a RUNX1 mutation, indicating higher risk
Article Synopsis
- Aberrations are a critical risk factor for both myelodysplastic neoplasms (MDS) and acute myeloid leukemia (AML), leading to challenges in distinguishing between the two conditions based on blast thresholds.
- In a study of 76 patients with aberrations, no significant genomic differences were found between MDS and AML, but overall survival was poor, particularly for certain AML subgroups.
- Key independent risk factors for mortality identified were having AML over MDS, a complex karyotype, multihit status, and the absence of hematopoietic cell transplant (HCT), suggesting these factors should guide treatment decisions.
Case: A 31-year-old man with a history of giant cell tumor of bone (GCTB) in the distal radius presents to clinic 9 years after en bloc distal radius resection. He was found to have a new soft tissue mass consistent with GCTB and new pulmonary metastases. Ultimately, he underwent excision of his soft tissue recurrence and partial lobectomy for his lung metastases.
View Article and Find Full Text PDFAlthough littoral cell angiomas (LCAs) are phenotypically well characterized, the antibodies used to support the diagnosis identify many other cells in the normal spleen, and some may be found in other angiomatous lesions. Based on a langerin/CD207+ LCA index case, langerin and other selected immunohistochemical staining was performed on 10 LCAs, 20 other splenic angiomatous lesions, and 7 reactive lymph nodes to further investigate the role of langerin as a diagnostic tool. Ninety percent (9/10) of LCAs were langerin positive, whereas only 1 (5%) of 20 other splenic vascular lesions was partially positive (P < .
View Article and Find Full Text PDFAssessing Residents' Frozen Section Skills for Endometrial Cancer.
Int J Gynecol Pathol
September 2016
Intraoperative frozen section (IFS) on endometrial cancer is an invaluable skill for pathologists-in-training to master. Within limited time constraints, pathologists are expected to determine tumor type, grade, and depth of myometrial invasion. During their training, pathology residents gradually gain experience in handling the majority of cases.
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