Publications by authors named "William Roland"

Article Synopsis
  • Hemophagocytic lymphohistiocytosis (HLH) is a rare and severe immune disorder that is hard to diagnose due to its varied causes and symptoms, often requiring intense medical care.
  • HLH can either be genetic (HLH syndrome) or acquired (HLH disease), triggered by instances like infections, autoimmune diseases, or cancers; this case study presents the first known instance of HLH caused by tularemia in an older female patient.
  • The patient was initially treated for suspected malignancy but switched to antimicrobial therapy after testing positive for tularemia, leading to a lengthy recovery period but ultimately highlighting the need for quick identification of triggering infections for more effective HLH treatment.
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Article Synopsis
  • * In rare cases, tularemia can cause unusual symptoms, including skin rashes and skeletal issues, such as osteomyelitis and prosthetic joint infections.
  • * This report discusses a 73-year-old man who developed a rare acute left knee prosthetic joint infection due to tularemia, successfully treated with doxycycline.
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Hemophilus influenzae is a gram-negative bacteria responsible for significant cases of invasive infections, especially in the pediatric population and in immunosuppressed adult patients. Before vaccination, most cases were frequently caused by capsulated or typeable variants. Due to the absence of effective vaccination against the nontypeable variant, it is now responsible for most invasive infections.

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The species, , causes human paragonimiasis in North America. As a foodborne disease, human infection with occurs after eating raw or undercooked crayfish containing metacercariae. Many risk factors have been described in the literature, including young adult age, male, alcohol consumption, outdoor activities involving rivers within Missouri, and ingesting raw or partially cooked crayfish.

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Actinomycosis is an indolent human infectious disease caused by gram-positive anaerobic filamentous bacteria . Despite its sluggish growth, clinical manifestations can be acute or chronic. Over the last five decades, a significant incidence decline in the western world is due to the discovery of effective antimicrobials and improved oral hygiene.

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Nontyphoidal (NTS) often cause self-limiting gastroenteritis in adults, known as salmonellosis. Salmonellosis has remained controlled in the United States due to intensive measures. Infrequently, these patients develop bacteremia and local or disseminated infections after salmonellosis.

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Article Synopsis
  • Certain bacterial species are common on animal skin and mucosa, and while often seen as contaminants in clinical samples, they have shown significant pathogenic potential and can cause serious infections.
  • Recent trends indicate a decline in diphtheria caused by one strain, while a related strain has increased its clinical impact in Europe, with similar virulence factors identified.
  • A case study highlights a rural farmer in Missouri who developed an unusual infection (prepatellar bursitis with abscess) due to this bacteria, marking the first documented instance of this condition in medical literature, leading to recovery through surgery and antibiotics.*
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Herpes simplex virus (HSV), a human alpha herpes virus, is responsible for most infections caused by herpes viruses worldwide. Among the herpes simplex viruses, both HSV 1 and 2 cause significant morbidity. HSV-2 accounts for most genital infections with extragenital complications involving the groin, thigh, or other pelvic areas.

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Isolated native pulmonic valve infective endocarditis (IE) is a rare occurrence. The most commonly involved valves in injection drug users are the tricuspid valve followed by mitral and then aortic valves. Most reported cases of methicillin-resistant (MRSA) IE involve multiple valves.

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Hemophagocytic lymphohistiocytosis (HLH) is also known as hemophagocytic syndrome. It is a lethal hematologic condition due to a dysregulated immune response which results in inappropriately activated macrophages damaging host tissues. Based on the etiology, HLH can be primary (genetic) or secondary (acquired).

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We describe a case of secondary syphilis presenting with osteomyelitis and tenosynovitis of the thumb. With appropriate therapy, the patient's symptoms resolved and seroreversion occurred. MRI showed improvement with treatment.

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spp., formerly ., are gram-negative, non-motile, traditionally opportunistic pathogens that are infrequent clinical isolates.

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Article Synopsis
  • - Daptomycin is a new type of antibiotic that effectively targets gram-positive bacteria and has a unique way of working; it's given once daily but needs dose adjustments for patients with kidney issues.
  • - There are some reports of resistance to daptomycin among gram-positive bacteria, and while it's usually well tolerated, it can lead to muscle problems, especially if combined with certain cholesterol-lowering medications.
  • - Currently approved for treating skin and soft-tissue infections, daptomycin shows potential for use in more serious infections like endocarditis and meningitis, making it a valuable addition to gram-positive infection treatments.
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