Neuroinflammation predicts disease progression in progressive supranuclear palsy.

Introduction: In addition to tau pathology and neuronal loss, neuroinflammation occurs in progressive supranuclear palsy (PSP). However, the prognostic value of the in vivo imaging markers for these processes in PSP remains unclear. We test the primary hypothesis that baseline in vivo imaging assessment of neuroinflammation in subcortical regions predicts clinical progression in patients with PSP.

In vivo PET imaging of neuroinflammation in familial frontotemporal dementia.

Introduction: We report patterns of neuroinflammation and abnormal protein aggregation in seven cases of familial frontotemporal dementia (FTD) with mutations in MAPT, GRN and C9orf72 genes.

Methods: Using positron emission tomography (PET), we explored the association of the distribution of activated microglia, as measured by the radioligand [C]PK11195, and the regional distribution of tau or TDP-43 pathology, indexed using the radioligand [F]AV-1451. The familial FTD PET data were compared with healthy controls.

Cortical Complexity Analyses and Their Cognitive Correlate in Alzheimer's Disease and Frontotemporal Dementia.

Background: The changes of cortical structure in Alzheimer's disease (AD) and frontotemporal dementia (FTD) are usually described in terms of atrophy. However, neurodegenerative diseases may also affect the complexity of cortical shape, such as the fractal dimension of the brain surface.

Objective: In this study, we aimed at assessing the regional patterns of cortical thickness and fractal dimension changes in a cross-sectional cohort of patients with AD and FTD.

F-AV1451 PET imaging and multimodal MRI changes in progressive supranuclear palsy.

Objectives: Progressive supranuclear palsy (PSP) is characterized by deposition of straight filament tau aggregates in the grey matter (GM) of deep nuclei and cerebellum. We examined the relationship between tau pathology (assessed via F-AV1451 PET) and multimodal MRI imaging using GM volume, cortical thickness (CTh), and diffusion tensor imaging (DTI).

Methods: Twenty-three people with clinically probable PSP-Richardson's syndrome (age 68.