Damage evolution during fracture by correlative microscopy with hyperspectral electron microscopy and laboratory-based microtomography.

Damage evolution during fracture of metals is a critical factor in determining the reliability and integrity of the infrastructure that the society relies upon. However, experimental techniques for directly observing these phenomena have remained challenged. We have addressed this gap by developing a correlative microscopy framework combining high-resolution hyperspectral electron microscopy with laboratory x-ray microtomography (XMT) and applied it to study fracture mechanisms in a steel inclusion system.

Infantile spasms and hyperekplexia associated with isolated sulfite oxidase deficiency.

Importance: Isolated sulfite oxidase deficiency (ISOD) causes severe intellectual disability, epilepsy, and shortened life expectancy. Intractable seizures are invariable in children with ISOD; however, to our knowledge, infantile spasms with a corresponding hypsarrhythmia pattern on electroencephalogram have never been reported. In addition, the nonepileptic paroxysmal movement disorder hyperekplexia has not previously been reported with ISOD.