Publications by authors named "William Randazzo"
IgG4-related disease is a newly recognized entity associated with autoimmune conditions involving almost every organ system. It is characterized by elevated serum IgG4 as well as mass like tissue infiltration by IgG4-positive plasma cells. Imaging findings are nonspecific, vary depending on the site of disease, and include mass like enlargement of the salivary or lacrimal glands and enlarged lymph nodes.
View Article and Find Full Text PDFRationale And Objectives: The variability in medical imaging evaluation across US medical schools inspired leading radiology student educators to develop the Alliance of Medical Student Educators in Radiology (AMSER) Standardized Exam (SE). This examination tests the understanding of essential material and concepts which are endorsed by the AMSER National Medical Student Curriculum in Radiology.
Materials And Methods: The AMSER Electronics Committee developed and deployed the AMSER SE using Radiology ExamWeb (REW), a previously-developed databank of imaging questions.
The daughter cyst sign is a specific indicator of an uncomplicated ovarian cyst and pathologically represents a stimulated ovarian follicle. This finding must be differentiated from an ectopic pregnancy in a patient who has the potential to become pregnant. We report an uncomplicated ovarian cyst in a 3-year-old female with McCune-Albright syndrome and precocious puberty mimicking an ectopic pregnancy.
View Article and Find Full Text PDFObjective: The purpose of this article is to develop a method for estimating embryo doses in CT.
Materials And Methods: Absorbed doses to the uterus (embryo) of a 70-kg woman were estimated using the ImPACT CT Patient Dosimetry Calculator. For a particular CT scan length, relative uterus doses and normalized plateau uterus doses were determined for a range of commercial CT scanners.
The theoretical framework proposed that cortisol and saliva alpha amylase (sAA) reactivitiy are vulnerabilities for antisocial behaviour. These indices of hypothalamic-pituitary-adrenal (HPA) and sympathetic-adrenal-medulary (SAM) components of the stress system, respectively, were considered vulnerabilities that also interact with the putative stressful transition of timing of puberty to predispose adolescents toward antisocial behaviour. The sample consisted of 8- to-13-year-old boys and girls (N=135) and a parent.
View Article and Find Full Text PDFArticle Synopsis
- Researchers explored how common genetic variations (H63D and C282Y) in the HFE gene, which is linked to iron overload, affect the secretion of specific proteins (cytokines and trophic factors) that play a role in neuroinflammation and neurodegenerative diseases.
- Using human neuroblastoma cells (SH-SY5Y), the study showed that these HFE variants altered iron levels and specifically impacted the release of the chemokine MCP-1, revealing a connection between the genotype and this inflammatory response.
- The findings suggested that even with similar iron levels, the two HFE variants led to different MCP-1 secretion levels, indicating a potential unique role
The stress response in adolescents with inattentive type ADHD symptoms.
Child Psychiatry Hum Dev
March 2008
Objective: To investigate the hypothalamic pituitary adrenal (HPA) axis response to a stressor in adolescents with inattentive type attention-deficit hyperactivity disorder symptoms (ADHD-I).
Method: Salivary cortisol was measured in threshold inattentive (TI, n = 7), moderately inattentive (MI, n = 13) and no symptom (comparison) (n = 19) groups of healthy, young adolescents, based on symptom counts, prior to and after an induced social/cognitive stressor.
Results: The TI group displayed a significant decrease in cortisol post stressor whereas both the MI and comparison groups showed an increase in cortisol.