Clinical implementation of chromosomal microarray analysis: summary of 2513 postnatal cases.

Background: Array Comparative Genomic Hybridization (a-CGH) is a powerful molecular cytogenetic tool to detect genomic imbalances and study disease mechanism and pathogenesis. We report our experience with the clinical implementation of this high resolution human genome analysis, referred to as Chromosomal Microarray Analysis (CMA).

Methods And Findings: CMA was performed clinically on 2513 postnatal samples from patients referred with a variety of clinical phenotypes.