Clinical outcomes from the CDC's Colorectal Cancer Screening Demonstration Program.

Background: Colorectal cancer remains the second leading cause of cancer-related deaths among US men and women. Screening rates have been slow to increase, and disparities in screening remain.

Methods: To address the disparity in screening for this high burden but largely preventable disease, the Centers for Disease Control and Prevention (CDC) designed and established a 4-year Colorectal Cancer Screening Demonstration Program (CRCSDP) in 2005 for low-income, under-insured or uninsured men and women aged 50 to 64 years in 5 participating US program sites.

Hyperthermia induces endoplasmic reticulum-mediated apoptosis in melanoma and non-melanoma skin cancer cells.

Hyperthermia has been revived as a promising approach for cancer treatment. To understand the underlying mechanisms of hyperthermic killing of cancer cells, we examined the cytotoxic effects of hyperthermia on various skin cancer cell lines using cell viability, morphological analyses, and caspase activation assays. Hyperthermia induced cytotoxicity in a time- and temperature-dependent manner.

Fixed cutaneous sporotrichosis in an adolescent boy: a case report.

We present a case of an adolescent boy with a 3-week history of 3 painless purulent erythematous ulcers with raised hyperkeratotic borders associated with regional lymphadenopathy on the medial aspect of the right antecubital fossa. There were no known initiating factors and no other significant associated signs or symptoms. The patient initially was treated with antibiotics, with no improvement.