Overpressure at the Macondo Well and its impact on the Deepwater Horizon blowout.

At the Macondo well, the overpressure (fluid pressure greater than hydrostatic) in the main reservoir is nearly identical to that within a stratigraphically equivalent sandstone at the Galapagos development 21 miles (34 km) to the south; we interpret that the reservoirs share a permeable, laterally extensive, and hydraulically connected aquifer. At Macondo, pore pressure approximately parallels the overburden stress to a depth of 17,640 ft (5,377 m) subsea and thereafter decreases abruptly by 1,200 psi (8.3 MPa) over 370 ft (113 m) as the main sandstone reservoir is approached.

A model of sensitivity and resistance to histone deacetylase inhibitors in diffuse large B cell lymphoma: Role of cyclin-dependent kinase inhibitors.

Diffuse large B cell lymphoma (DLBCL) is an aggressive form of non-Hodgkin lymphoma. While the initial treatment strategy is highly effective, relapse occurs in 40% of cases. Histone deacetylase inhibitors (HDACi) are a promising class of anti-cancer drugs but their single agent efficacy against relapsed DLBCL has been variable, ranging from few complete/partial responses to some stable disease.