Efficient farnesylation of an extended C-terminal C() sequence motif expands the scope of the prenylated proteome.

Protein prenylation is a post-translational modification that has been most commonly associated with enabling protein trafficking to and interaction with cellular membranes. In this process, an isoprenoid group is attached to a cysteine near the C terminus of a substrate protein by protein farnesyltransferase (FTase) or protein geranylgeranyltransferase type I or II (GGTase-I and GGTase-II). FTase and GGTase-I have long been proposed to specifically recognize a four-amino acid C C-terminal sequence within their substrates.

Comparative evaluation of calcium hypochlorite and sodium hypochlorite on soft-tissue dissolution.

Introduction: The aim of this study was to compare in vitro the tissue-dissolution properties of 5% and 10% calcium hypochlorite (Ca(OCl)(2)) with two concentrations (1.36% and 4.65%) of proprietary sodium hypochlorite (NaOCl) on bovine muscle tissue.

Dental dilemmas: Endodontics or dental implants?

Unlabelled: This narrative review explores treatment planning options in restorative dentistry. The growth of dental implants, as an accessible and predictable treatment option, gives practitioners a useful tool for managing the missing tooth or teeth with a hopeless prognosis. Traditionally, endodontics and fixed prosthodontics have been used to restore teeth and spaces where the outlook for such treatment appears reasonable.

Management of the compromised tooth.

Modern endodontic and restorative techniques allow some teeth previously thought to be unsaveable to be aesthetically restored to function. This paper discusses the use of such techniques and is illustrated with a case report.

A prospective clinical study of periradicular surgery using mineral trioxide aggregate as a root-end filling.

A prospective outcome study of periradicular surgery using microsurgical techniques and root-end filling with mineral trioxide aggregate (MTA) was performed. Nonhealing endodontically treated teeth (n = 321) were included in the study. Surgery was completed under local anesthesia using a standardized clinical protocol.

Retention of quartz-fibre endodontic posts with a self-adhesive dual cure resin cement.

This study examines retention of a quartz-fibre endodontic post cemented in extracted human teeth using two cement types. Fifty-four extracted buman central incisor teeth were prepared for a tapered quartz-fibre post. Posts were cemented in 28 teeth using conventional resin cement (RelyX ARC), and 26 teeth using self-adhesive resin cement (RelyX Unicem).

In vitro evaluation of furcal perforation repair using mineral trioxide aggregate or resin modified glass lonomer cement with and without the use of the operating microscope.

This study evaluated in vitro the effect of using the operating microscope on repairing furcation perforations using Vitrebond or mineral trioxide aggregate. Forty-six human molar teeth were mounted into a jig attached to a simulated jaw. The teeth were allocated randomly to four groups (n = 10).