Effect of corticosteroid-antibiotic agents on granulation tissue in a murine model.

Objective: To compare the effects of 3 commonly used ototopical corticosteroid-antibiotic agents, currently available for use in the treatment of inflammatory conditions of the external and middle ear, on granulation tissue in an established murine model of wound healing.

Subjects: Twelve C57/BL6J mice.

Design: Eight-millimeter wounds, created bilaterally on the dorsum of the mice, were treated with combinations of 0.

Congenital cholesteatoma.

Purpose Of Review: Congenital cholesteatomas have historically been considered a rare disorder. However, a review of the literature reveals an incidence ranging from 4 to 24%, and these values are probably underestimated. This article summarizes the general diagnostic criteria of congenital cholesteatomas, their usual presenting symptoms and findings, perioperative studies, a proposed staging system to assist with predicting postoperative outcomes, general surgical procedures, and recidivism rates.

Effects of Clarion electrode design on mapping levels in children.

The design of the placement of the Clarion cochlear implant's intracochlear electrode array has undergone 2 revisions since its introduction, each to improve modiolar proximity. Stimulation with modiolar proximity may reduce current requirements for threshold levels and most comfortable levels of stimulation. This study analyzed the effects of electrode design on programming levels for deaf children implanted with the 3 cochlear implant designs and followed at The Children's Hospital of Philadelphia.

Screening and prevention of hearing loss in children.

Congenital hearing loss is the most common neurosensory handicap in neonates. Recently, technology has become available that has allowed states to implement universal screening programs at a relatively low cost and with minimal expertise needed for hospital personnel to operate the screening machines. In successful programs, the age of diagnosis has been reduced from 2(1/2) years to 3 to 6 months.

A staging system for congenital cholesteatoma.

Objective: To develop a staging system for congenital cholesteatoma in predicting the likelihood of residual disease.

Design: Retrospective analysis of data from a case series, to identify predictors of residual disease.

Setting: Tertiary care pediatric hospital.

Congenital cholesteatoma: 20 years' experience at The Children's Hospital of Philadelphia.

Objective: We report our experience with congenital cholesteatoma over a span of 20 years with an emphasis on presenting characteristics and predictors of outcome.

Methods: We conducted a retrospective review from 1981 through 2000.

Results: One hundred seventy-two congenital cases were identified in 167 patients.