Publications by authors named "William P Israel"
Article Synopsis
- A new subset of macrophages called iron-rich tumor-associated macrophages (iTAMs) was identified, marked by high levels of intracellular iron and involvement in angiogenesis and immunosuppression in tumors.
- Two types of iTAMs were characterized based on their location and gene expression: perivascular (pviTAM) and stromal (stiTAM).
- The endothelin receptor type B (Ednrb) was identified as a specific marker for iTAMs, and its deletion reduced tumor growth, while the transcription factor Bach1 was found to regulate iTAM functions by inhibiting Ednrb expression.
