Publications by authors named "William Oc Cookson"
Article Synopsis
- Lung carcinoids (L-CDs) are rare neuroendocrine tumors more common in women and categorized into typical (TCs) and atypical carcinoids (ACs), with ACs having worse prognosis.
- A study of 15 L-CDs revealed two distinct subtypes, L-CD-PanC, likened to pancreatic tumors, and L-CD-NeU, akin to neuroendocrine tumors, differentiated by their genetic and epigenetic profiles.
- L-CD-PanC tumors showed changes related to metabolic and pancreatic genes, while L-CD-NeU tumors exhibited high mutational loads and specific environmental mutational signatures, suggesting different underlying causes and potential treatment implications.
