Publications by authors named "William N Bell"
Purpose: Interleukin-18 (IL-18) is an immunostimulatory cytokine with antitumor activity in preclinical models. A phase I study of recombinant human IL-18 (rhIL-18) was done to determine the toxicity, pharmacokinetics, and biological activities of rhIL-18 administered at different doses in two different schedules to patients with advanced cancer.
Experimental Design: Cohorts of three to four patients were given escalating doses of rhIL-18 as a 2-h i.
Article Synopsis
- The study investigated the safety, effectiveness, and pharmacokinetics of recombinant human IL-18 (rhIL-18) in patients with advanced cancer through a phase I trial.
- Common side effects reported included chills, fever, and hypotension, but overall, patients tolerated the treatment well without reaching a maximum tolerated dose.
- Biological effects observed after treatment with rhIL-18 included immune activation and increases in specific immune markers, suggesting potential for further research into its antitumor capabilities.
Purpose: To compare the efficacy and tolerability of eniluracil (EU)/fluorouracil (5-FU) with that of 5-FU/leucovorin (LV) as first-line therapy for patients with metastatic/advanced colorectal cancer.
Patients And Methods: This multicenter, randomized, open-label, phase III study (FUMA3008) conducted in the United States and Canada compared the safety and efficacy of EU/5-FU (11.5 mg/m(2)/1.