Publications by authors named "William Mullins"

Article Synopsis
  • Chronic active lesions (CAL) in multiple sclerosis (MS) persist even with high-efficacy treatments like B-cell depletion, making it important to understand how targeting specific lymphocyte populations could improve treatment outcomes.
  • A study was conducted analyzing lymphocyte transcriptomes and using machine learning to predict the effects of depleting B-cells, followed by MRI assessments over two years on 72 MS patients.
  • Findings revealed that depleting B-cells had limited impact on microglial inflammation and did not lead to the disappearance of paramagnetic rims in treated patients, indicating that anti-CD20 therapies may not effectively mitigate chronic inflammation in MS.
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Background: The unequal distribution of academic and professional outcomes between different minority groups is a pervasive issue in many fields, including surgery. The implications of differential attainment remain significant, not only for the individuals affected but also for the wider health care system. An inclusive health care system is crucial in meeting the needs of an increasingly diverse patient population, thereby leading to better outcomes.

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Microglial activation is readily detected following cerebral ischemia/reperfusion-induced injury. Activated microglia polarize into either classic pro-inflammatory M1 or protective M2 microglia following ischemia/reperfusion-induced injury. Melatonin is protective immediately after ischemia/reperfusion-induced brain injury.

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Robotic surgery training has lacked evidence-based standardisation. We aimed to determine the effectiveness of adjunctive interactive virtual classroom training (VCT) in concordance with the self-directed Fundamentals of Robotic Surgery (FRS) curriculum. The virtual classroom is comprised of a studio with multiple audio-visual inputs to which participants can connect remotely via the BARCO weConnect platform.

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Background: Retained intravascular catheter fragments (RICF) are a rare complication of implantable vascular access device (IVAD) removal for which there is limited understanding of aetiology. There is a varied approach to management among the currently published literature.

Aims: The aim of this study was to establish incidence, risk factors, and outcomes for RICF after attempted removal of IVADs.

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Objective: This study evaluated the efficacy of virtual classroom training (VCT) in comparison to face-to-face training (FFT) and non-interactive computer-based learning (CBL) for basic surgical skills training.

Design: This was a parallel-group, non-inferiority, prospective randomised controlled trial with three intervention groups conducted in 2021. There were three intervention groups with allocation ratio 1:1:1.

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Background: Traditional face-to-face training (FFT) for basic surgical skills is inaccessible and resource-intensive. Noninteractive computer-based learning is more economical but less educationally beneficial. Virtual classroom training (VCT) is a novel method that permits distanced interactive expert instruction.

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In a series of human cadaveric experiments, Dr. Paul Segond first described the avulsion injury occurring at the anterolateral tibial plateau that later took his name. The fracture is thought to arise as a consequence of excessive tibia internal rotation which often also elicits damage to other connective tissue of the knee.

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