Antiapoptotic role of Agaricus blazei extract in rodent model of Parkinson's disease.

Rotenone is a pesticide that has been shown to induce the pathological symptoms of Parkinson's disease (PD) in both cellular and animal models. In this study, we investigated the protective effect of Agaricus blazei extract on rotenone-induced dopaminergic degeneration and apoptosis in mice model. A.

Demethoxycurcumin ameliorates rotenone-induced toxicity in rats.

Rotenone, an environmental toxin, is used to induce neurodegeneration in both the cellular and animal model of Parkinson's disease. Demethoxycurcumin (DMC), derivative of curcumin has been reported to have antioxidant and anti-inflammatory characteristics in and PD conditions. The present study was aimed to evaluate the efficacy of DMC in the management of neurodegeneration in PD.