Polymer drug conjugates containing memantine, tacrine and cinnamic acid: promising nanotherapeutics for the treatment of Alzheimer's disease.

Aim: To prepare polymer-drug conjugates containing a combination of memantine, tacrine, and )--(3-aminopropyl)cinnamide, promising therapeutics for the treatment of neurodegenerative disorders.

Methods: The conjugates were characterised by HNMR, particle size analysis, SEM, LC-MS, TEM/EDX, and XRD, followed by anti-acetylcholinesterase and drug release studies.

Results: H NMR analysis revealed successful drug conjugation with drug mass percentages in the range of 1.