Vascular Disease Is Associated With the Expression of Genes for Intestinal Cholesterol Transport and Metabolism.

Context: Intestinal cholesterol metabolism is important in influencing postprandial lipoprotein concentrations, and might be important in the development of vascular disease.

Objective: This study evaluated associations between expression of intestinal cholesterol metabolism genes, postprandial lipid metabolism, and endothelial function/early vascular disease in human subjects.

Design/patients: One hundred patients undergoing routine oesophago-gastro-duodenoscopy were recruited.

Postprandial Studies Uncover Differing Effects on HDL Particles of Overt and Subclinical Hypothyroidism.

Background: Overt hypothyroidism (OH) is associated with abnormal lipid metabolism and endothelial dysfunction under fasting conditions. The balance of evidence suggests similar but less marked abnormalities in subclinical hypothyroidism (SCH). There are few data regarding the metabolic and vascular effects of OH or SCH under postprandial conditions.