De novo tissue formation using custom microporous annealed particle hydrogel provides long-term vocal fold augmentation.

Biomaterial-enabled de novo formation of non-fibrotic tissue in situ would provide an important tool to physicians. One example application, glottic insufficiency, is a debilitating laryngeal disorder wherein vocal folds do not fully close, resulting in difficulty speaking and swallowing. Preferred management of glottic insufficiency includes bulking of vocal folds via injectable fillers, however, the current options have associated drawbacks including inflammation, accelerated resorption, and foreign body response.

A Simple and Reproducible In Vivo Rabbit Phonation Model for Glottic Insufficiency.

Objective: The objective of this study is to describe an in vivo rabbit phonation model for glottic insufficiency that is simple and reproducible by means of unilateral transcricothyroid laryngeal muscle stimulation and high-speed video recordings of evoked phonation.

Study Design: Nonrandomized controlled animal trial.

Setting: Academic medical center.

Change in parathyroid hormone levels from baseline predicts hypocalcemia following total or completion thyroidectomy.

Background: This study aims to identify the strongest predictor of postoperative hypocalcemia following thyroid surgery.

Methods: Study of patients who underwent total/completion thyroidectomy. No patients received postoperative calcium supplementation.

Airway Management in Substernal Goiter Surgery.

Objective(s): To review the experience of 3 hospitals with airway management during surgery for substernal goiter and identify preoperative factors that predict the need for advanced airway management techniques.

Methods: A retrospective chart review between 2009 and 2017 of patients with substernal goiter treated surgically at 1 of 3 hospitals was performed.

Results: Of the 179 patients included in the study, 114 (63.