Publications by authors named "William M Savage"
Article Synopsis
- - Disruptive behavior disorders (DBDs), which include conduct disorder and oppositional defiant disorder, often overlap with ADHD, but there is a significant difference in their treatment and societal perceptions, pointing to a need for better diagnostic understanding.
- - Previous smaller studies have hinted at racial disparities in DBD diagnoses as compared to ADHD, prompting a larger investigation into these disparities using a comprehensive dataset of pediatric inpatients.
- - The study found that certain racial groups, including Native American, Asian, Black, and Hispanic children, were more likely to be diagnosed with DBDs when presenting symptoms similar to those of ADHD, highlighting important questions regarding race and mental health diagnoses.
Glioblastoma (GBM) is the most common primary brain cancer, comprising half of all malignant brain tumors. Patients with GBM have a poor prognosis, with a median survival of 14-15 months. Current therapies for GBM, including chemotherapy, radiotherapy, and surgical resection, remain inadequate.
View Article and Find Full Text PDFAcute ischemic stroke remains the primary cause of disability worldwide. For patients with large vessel occlusions, intravenous thrombolysis followed by mechanical thrombectomy remains the standard of care. Revascularization of the large vessel is typically successful.
View Article and Find Full Text PDFThe prognosis for glioblastoma has remained poor despite multimodal standard of care treatment, including temozolomide, radiation, and surgical resection. Further, the addition of immunotherapies, while promising in a number of other solid tumors, has overwhelmingly failed in the treatment of gliomas, in part due to the immunosuppressive microenvironment and poor drug penetrance to the brain. Local delivery of immunomodulatory therapies circumvents some of these challenges and has led to long-term remission in select patients.
View Article and Find Full Text PDFReaching a Tipping Point for Neurorehabilitation Research: Obstacles and Opportunities in Trial Design, Description, and Pooled Analysis.
Neurorehabil Neural Repair
November 2022
The record-breaking pace of COVID-19 vaccine development and implementation depended heavily on collaboration among academic, government, and commercial stakeholders, especially through data-sharing and robust multicenter trials. Collaborative efforts have not been as fruitful in fields such as neurorehabilitation, where non-pharmacological interventions play a much larger role. Barriers to translating scientific advancements into clinical practice in neurorehabilitation include pervasively small study sizes, exacerbated by limited funding for non-pharmacological multicenter clinical trials; difficulty standardizing-and adequately describing-non-pharmacological interventions; and a lack of incentives for individual patient-level data-sharing.
View Article and Find Full Text PDFArticle Synopsis
- Transcutaneous spinal cord stimulation (TSCS) shows promise in improving motor and autonomic function in the spinal cord, specifically for hand movements.
- A new setup for cervical TSCS was tested where electrodes are placed at different cervical and thoracic levels, and its effects were measured when paired with motor cortex or median nerve stimulation.
- Results indicated that TSCS can enhance hand muscle responses to motor cortex stimulation, particularly when the stimulation is closely timed, suggesting a potential method for improving hand function in individuals with spinal cord injuries, though further research is needed with more participants.