Publications by authors named "William M R Matshe"

Uncomplicated malaria is effectively treated with oral artemisinin-based combination therapy (ACT). Yet, there is an unmet clinical need for the intravenous treatment of the more fatal severe malaria. There is no combination intravenous therapy for uncomplicated due to the nonavailability of a water-soluble partner drug for the artemisinin, artesunate.

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Aim: To prepare polymer-drug conjugates containing a combination of memantine, tacrine, and )--(3-aminopropyl)cinnamide, promising therapeutics for the treatment of neurodegenerative disorders.

Methods: The conjugates were characterised by HNMR, particle size analysis, SEM, LC-MS, TEM/EDX, and XRD, followed by anti-acetylcholinesterase and drug release studies.

Results: H NMR analysis revealed successful drug conjugation with drug mass percentages in the range of 1.

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Malaria is one of the oldest infectious diseases that afflict humans and its history extends back for millennia. It was once prevalent throughout the globe but today it is mainly endemic to tropical regions like sub-Saharan Africa and South-east Asia. Ironically, treatment for malaria has existed for centuries yet it still exerts an enormous death toll.

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