Incidence of tardive dyskinesia with atypical versus conventional antipsychotic medications: a prospective cohort study.

Objective: Most previous studies of the incidence of tardive dyskinesia with atypical antipsychotics compared with conventional antipsychotics have not had tardive dyskinesia as their primary focus. The current study aimed to compare the incidence of tardive dyskinesia with atypical vs conventional antipsychotics using methods similar to those from a previous prospective cohort study at our site in the 1980s.

Method: Three hundred fifty-two initially tardive dyskinesia-free psychiatric outpatients (diagnosed at baseline using the Structured Clinical Interview for DSM-IV) were examined for a new diagnosis of tardive dyskinesia (using the Abnormal Involuntary Movement Scale and Glazer-Morgenstern criteria) every 6 months for up to 4 years at a community mental health center.

Pain and the brain.

Chronic pain is difficult to diagnose and treat, and is often comorbid with psychiatric conditions. Pain and mood disorders may share neurologic pathways and a neurochemical base. For example, depression is associated with abnormalities in serotonin and norepinephrine, neurotransmitters that also modulate the endogenous analgesic system.

Tactics and technologies to manage nonadherence in patients with schizophrenia.

The occurrence of treatment nonadherence among patients with schizophrenia is clinically significant. However, studies show that clinicians do not make systematic efforts to identify and monitor it over time. This paper reviews the various tactics for identifying and monitoring adherence behavior.