Skeletal muscle microvascular and interstitial PO2 from rest to contractions.

Key Points: Oxygen pressure gradients across the microvascular walls are essential for oxygen diffusion from blood to tissue cells. At any given flux, the magnitude of these transmural gradients is proportional to the local resistance. The greatest resistance to oxygen transport into skeletal muscle is considered to reside in the short distance between red blood cells and myocytes.

Novel instrumentation to determine peel force in vivo and preliminary studies with adhesive skin barriers.

Background/purpose: Adhesive barriers secure medical devices to skin. Laboratory adhesion models are not predictive of in vivo performance. The objectives of these studies were to validate a novel peel force device, and to investigate relationships between barrier formulations, barrier width, subjective discomfort during barrier removal, and substrates.

Validity and reliability of a pad test model using a simulated urine leak and healthy continent females.

The objective of this study was to determine the validity and reliability of a modified pad test to assess urinary incontinence. Urine leakage was simulated using normal saline that was dosed onto super-absorbent incontinence pads, and worn by healthy continent females over two sequential 12-hour time periods. The results indicate that the two x 12-hour pad test provides a reliable assessment of urine leak in female subjects.

Salivary immunoglobulin A response to a collegiate rugby game.

Transient fluctuations in immune function after heavy exercise have been linked to an increased incidence of infection in athletes. Several parameters of immunity, including salivary immunoglobulin A (IgA), are affected by heavy exercise in the laboratory setting. However, few observations have been made during true competition.

Dynamics of microvascular oxygen pressure during rest-contraction transition in skeletal muscle of diabetic rats.

Type I diabetes reduces dramatically the capacity of skeletal muscle to receive oxygen (QO(2)). In control (C; n = 6) and streptozotocin-induced diabetic (D: n = 6, plasma glucose = 25.3 +/- 3.

Effects of prior contractions on muscle microvascular oxygen pressure at onset of subsequent contractions.

In humans, pulmonary oxygen uptake (.V(O2)) kinetics may be speeded by prior exercise in the heavy domain. This "speeding" arises potentially as the result of an increased muscle O(2) delivery (.