Publications by authors named "William L Michell"
Critically ill patients frequently display unexplained or incompletely explained features of gastrointestinal (GI) dysfunction, including gastric stasis, ileus, and diarrhea. This makes nutrition delivery challenging, and may contribute to poor outcomes. The typical bowel dysfunction seen in severely ill patients includes retarded gastric emptying, unsynchronized intestinal motility, and intestinal hyperpermeability.
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- Corticotropin-releasing factor (CRF) levels were studied in patients with traumatic shock and those undergoing elective abdominal surgery to assess its impact on gut function.
- Comparison revealed that shocked patients had significantly higher plasma CRF levels than those in elective surgery, although intestinal tissue CRF levels were similar.
- Results indicated that shock was linked to increased intestinal permeability and delayed gastric emptying, contributing to longer stays in the ICU for affected patients.