Publications by authors named "William Kuenstner"
Background: Thyroid cancer (TC) remains a significant clinical challenge worldwide, with a subset of patients facing aggressive disease progression and therapeutic resistance. Immune checkpoint inhibitors targeting programmed death-ligand 1 (PD-L1) have emerged as promising therapeutic approaches for various malignancies, yet their efficacy in TC remains uncertain. The objective of this study was to investigate PD-L1 expression in aggressive TC and its association with histological subtypes, molecular mutation, and progression-free survival.
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- - 22q11.2 deletion syndrome is a genetic condition caused by a small deletion on chromosome 22, often diagnosed in childhood, with various health issues associated with it.
- - A 38-year-old woman with a history of primary hypothyroidism and other health concerns was evaluated and found to have a significant genetic deletion linked to this syndrome.
- - The case underscores the difficulties in diagnosing 22q11.2 DS and the effects of a late diagnosis on managing the condition effectively.
A Rare Case of Persistent Multifocal Cribriform-Morular Thyroid Carcinoma.
AACE Clin Case Rep
January 2024
Background/objective: Cribriform-morular thyroid carcinoma (CMTC) was considered a variant of papillary thyroid carcinoma (PTC) but is a separate entity in the 2022 World Health Organization classification. CMTC has an association with familial adenomatous polyposis (FAP). Our objective is to report a case of CMTC who was subsequently diagnosed with FAP, to highlight these associated entities and implications for management.
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