Publications by authors named "William Julian"
Prostate specific membrane antigen (PSMA)-targeted radioligand therapies represent a highly effective treatment for metastatic prostate cancer. However, high and sustain uptake of PSMA-ligands in the salivary glands led to dose limiting dry mouth (xerostomia), especially with α-emitters. The expression of PSMA and histologic analysis couldn't directly explain the toxicity, suggesting a potential off-target mediator for uptake.
View Article and Find Full Text PDFBackground: Centralization of hepatopancreatobiliary procedures to more experienced centers has been recommended but remains controversial. Hospital volume and risk-stratified mortality rates (RSMR) are metrics for interhospital comparison. We compared facility operative volume with facility RSMR as a proxy for hospital quality.
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- * Research utilizing atomic force microscopy revealed that 2,4-DAPG causes observable damage to the outer membranes of bacteria and leads to intracellular leakage over time.
- * 2,4-DAPG's ability to inhibit metabolic activity suggests it alters bacterial behaviors like quorum-sensing, with certain concentrations decreasing biosynthesis of acyl-homoserine lactones without killing the cells outright.
Article Synopsis
- - The study focuses on a newly discovered antibiotic, 5812-A/C, derived from the metabolite INA-Ac-5812, which features a cyclic peptide structure linked to an arabinose residue and has a partial amino acid sequence identified.
- - 5812-A/C is found to have similar inhibitory effects on Gram-positive bacteria, including methicillin-resistant strains, as the lipopeptide antibiotic daptomycin, but it works by disrupting cell membrane integrity differently and is calcium-dependent.
- - Unlike daptomycin, 5812-A/C can penetrate mature biofilms and has shown weak cytotoxicity, yet it does not cause hemolysis in red blood cells, indicating its potential as a broad
An anomalous circumflex to left atria fistula following previous excision of an atrial myxoma was successfully occluded percutaneously using a covered stent. The intervention was technically challenging but was possible using a Magnum guide wire via a left radial approach.
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