Publications by authors named "William J Bement"
Involvement of Toll-like receptor 4 in acetaminophen hepatotoxicity.
Herbert C Yohe Kimberley A O'Hara Jane A Hunt Tamar J Kitzmiller Sheryl G Wood Jenna L Bement William J Bement
Am J Physiol Gastrointest Liver Physiol
June 2006
Article Synopsis
- The study investigates the role of Toll-like receptor 4 (TLR4) in liver damage caused by acetaminophen (APAP) when influenced by alcohol.
- Ethanol pretreatment showed no liver damage in certain mice (C3H/HeJ) with mutated TLR4, while the wild type (C3H/HeN) experienced increased liver harm after APAP exposure.
- The findings suggest that TLR4 enhances the toxic effects of APAP in the presence of alcohol, potentially increasing inflammation and liver injury.
Two major risk factors for porphyria cutanea tarda (PCT) are alcohol consumption and homozygosity for the C282Y mutation in the hereditary hemochromatosis gene (HFE). We recently described an animal model for alcohol-induced uroporphyria, using Hfe(-/-) mice. In the present study we show that this effect is dependent on genetic background and ethanol dose.
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- Two key risk factors for porphyria cutanea tarda (PCT) are alcohol consumption and having two copies of the C282Y mutation in the hereditary hemochromatosis gene.
- Researchers created an animal model using Hfe knockout mice given 10% ethanol in their water, which showed biochemical changes related to PCT, including increased uroporphyrin in urine and liver after several months.
- The study concludes that ethanol influences liver iron metabolism, making the ethanol-treated Hfe(-/-) mice a suitable model for examining how alcohol contributes to PCT.
Article Synopsis
- The study investigates the role of hepatic cytochrome P450 (CYP)1A2 and iron levels in mice, specifically looking at how these factors contribute to uroporphyria, a condition characterized by the accumulation of porphyrins.
- Different genetic backgrounds of C57BL/6 mice (Cyp1a2 knockout, heterozygotes, and wild types) were compared, showing that varying levels of CYP1A2 significantly influence uroporphyrin accumulation, particularly when mice are treated with 5-aminolevulinic acid (ALA) and iron, as well as polyhalogenated aromatic compounds like PCB126.
- The research revealed that high hepatic iron levels (over 850