Publications by authors named "William Herskowitz"
Purpose: To develop and validate a deep learning (DL) model to differentiate ocular surface squamous neoplasia (OSSN) from pterygium and pinguecula using high resolution anterior segment optical coherence tomography (AS-OCT).
Design: Retrospective Diagnostic Accuracy Study METHODS: xxx.
Setting: Single Center STUDY POPULATION: All eyes with a clinical or biopsy-proven diagnosis of OSSN, pterygium, or pinguecula that received AS-OCT imaging.
Antibiotic resistance, driven by the rise of pathogens like VRE and MRSA, poses a global health threat, prompting the exploration of antimicrobial peptides (AMPs) as alternatives to traditional antibiotics. AMPs, known for their broad-spectrum activity and structural flexibility, share characteristics with intrinsically disordered proteins, which lack a rigid structure and play diverse roles in cellular processes. This study aims to quantify the intrinsic disorder and liquid-liquid phase separation (LLPS) propensity in AMPs, advancing our understanding of their antimicrobial mechanisms and potential therapeutic applications.
View Article and Find Full Text PDFArticle Synopsis
- High-resolution optical coherence tomography (HR-OCT) helps doctors see detailed pictures of eye surface problems, making it easier to diagnose and treat them.
- It can show different types of issues like tumors and helps tell them apart, even when they look similar.
- HR-OCT is important for doctors because it allows them to check how well treatments are working and keep an eye on any tumors that might grow back.
Article Synopsis
- The study focuses on refractory periorbital dermatitis, a chronic condition that causes discomfort and cosmetic concerns, while highlighting the limited treatment options available.
- Researchers conducted a retrospective review of 45 patients treated over a decade, primarily noting the demographics (average age 60.3, mostly women and Caucasian) and the most commonly used medications.
- The findings suggest that many patients, particularly those using triamcinolone cream, experienced refractory symptoms, leading to the conclusion that a better understanding of treatment regimens may improve medical management approaches for this condition.