Challenges to the central nervous system during human spaceflight missions to Mars.

Space travel presents a number of environmental challenges to the central nervous system, including changes in gravitational acceleration that alter the terrestrial synergies between perception and action, galactic cosmic radiation that can damage sensitive neurons and structures, and multiple factors (isolation, confinement, altered atmosphere, and mission parameters, including distance from Earth) that can affect cognition and behavior. Travelers to Mars will be exposed to these environmental challenges for up to 3 years, and space-faring nations continue to direct vigorous research investments to help elucidate and mitigate the consequences of these long-duration exposures. This article reviews the findings of more than 50 years of space-related neuroscience research on humans and animals exposed to spaceflight or analogs of spaceflight environments, and projects the implications and the forward work necessary to ensure successful Mars missions.

Changes in gain of horizontal vestibulo-ocular reflex during spaceflight.

Background: The vestibulo-ocular reflex (VOR) is a basic function of the vestibular system that stabilizes gaze during head movement. Investigations on how spaceflight affects VOR gain and phase are few, and the magnitude of observed changes varies considerably and depends on the protocols used.

Objective: We investigated whether the gain and phase of the VOR in darkness and the visually assisted VOR were affected during and after spaceflight.

Fronto-Parietal Brain Areas Contribute to the Online Control of Posture during a Continuous Balance Task.

Neuroimaging studies have provided evidence for the involvement of frontal and parietal cortices in postural control. However, the specific role of these brain areas for postural control remains to be known. Here, we investigated the effects of disruptive transcranial magnetic stimulation (TMS) over supplementary motor areas (SMA) during challenging continuous balance task in healthy young adults.

Effects of speed and direction of perturbation on electroencephalographic and balance responses.

The modulation of perturbation-evoked potential (PEP) N1 as a function of different biomechanical characteristics of perturbation has been investigated before. However, it remains unknown whether the PEP N1 modulation contributes to the shaping of the functional postural response. To improve this understanding, we examined the modulation of functional postural response in relation to the PEP N1 response in ten healthy young subjects during unpredictable perturbations to their upright stance-translations of the support surface in a forward or backward direction at two different amplitudes of constant speed.

Cortical control of upright stance in elderly.

This study examined differences between young and elderly volunteers in cortical involvement to human posture control during quiet stance with normal and altered sensory stimulation (Experiment-1), and biomechanical perturbations (Experiment-2). The primary focus of the first part was to monitor changes in cortical activity when unexpectedly altering the sensory conditions of upright stance, such as switching from stable (eyes open, fixed support surface) to less-stable (eyes closed, sway-referenced support surface) conditions. Our results demonstrate increased cortical activations in delta (0.

Bed Rest and Intermittent Centrifugation Effects on Human Balance and Neuromotor Reflexes.

Introduction: The effects of repeated centrifugation in association with head-down tilt (HDT) bed rest (BR) on the mediation of basic reflexes associated with the major postural muscles was investigated as a potential countermeasure for maintaining balance control and neuromotor reflex function.

Methods: There were 15 male volunteers who were exposed to 21 d of 6° HDT-BR. Eight were treated with daily 1-h artificial gravity (AG) exposures aboard a short radius centrifuge that provided 1-g footward loading at heart level.

Assessing multiple muscle activation during squat movements with different loading conditions - an EMG study.

Surface electromyography (EMG) is a valuable tool in clinical diagnostics and research related to human neuromotor control. Non-linear analysis of EMG data can help with detection of subtle changes of control due to changes of external or internal constraints during motor tasks. However, non-linear analysis is complex and results may be difficult to interpret, particularly in clinical environments.

Cortical activity modulations underlying age-related performance differences during posture-cognition dual tasking.

To date, no systematic research investigating cortical correlates of performance changes in dual tasking has been reported in the elderly population. Thus, we monitored whole-scalp cortical activations (EEG) during both single task and posture-cognition dual tasking with the main goal of understanding cortical activity modulations underlying age-related differences on posture-cognition dual tasking conditions. Postural and cognitive data analyses showed that elderly people had decreased cognitive performance even during challenging single cognitive tasks.

Motor Control Performance During Rapid Voluntary Movements of Elbow and Knee.

Knowledge of motor control differences during rapid goal-directed movements of the upper and lower limbs could be useful in improving rehabilitation protocols. The authors investigated performance and control differences between elbow and knee joints and between different contraction types (concentric vs. eccentric) during rapid movements under externally applied load.

Measuring multiple neuromuscular activation using EMG - a generalizability analysis.

Analysis of electromyography (EMG) data has been shown to be valuable in biomedical and clinical research. However, most analysis tools do not consider the non-linearity of EMG data or the synergistic effects of multiple neuromuscular activities. The SYNERGOS algorithm was developed to assess a single index based on non-linear analysis of multiple neuromuscular activation (MNA) of different muscles.

Assessing Sensorimotor Function Following ISS with Computerized Dynamic Posturography.

Introduction: Postflight postural ataxia reflects both the control strategies adopted for movement in microgravity and the direct effects of deconditioning. Computerized dynamic posturography (CDP) has been used during the first decade of the International Space Station (ISS) expeditions to quantify the initial postflight decrements and recovery of postural stability.

Methods: The CDP data were obtained on 37 crewmembers as part of their pre- and postflight medical examinations.

Smartphone-based tactile cueing improves motor performance in Parkinson's disease.

Introduction: Visual and auditory cueing improve functional performance in Parkinson's disease (PD) patients. However, audiovisual processing shares many cognitive resources used for attention-dependent tasks such as communication, spatial orientation, and balance. Conversely, tactile cues (TC) may be processed faster, with minimal attentional demand, and may be more efficient means for modulating motor-cognitive performance.

Artificial gravity as a countermeasure for mitigating physiological deconditioning during long-duration space missions.

In spite of the experience gained in human space flight since Yuri Gagarin's historical flight in 1961, there has yet to be identified a completely effective countermeasure for mitigating the effects of weightlessness on humans. Were astronauts to embark upon a journey to Mars today, the 6-month exposure to weightlessness en route would leave them considerably debilitated, even with the implementation of the suite of piece-meal countermeasures currently employed. Continuous or intermittent exposure to simulated gravitational states on board the spacecraft while traveling to and from Mars, also known as artificial gravity, has the potential for enhancing adaptation to Mars gravity and re-adaptation to Earth gravity.

Short-arm centrifugation as a partially effective musculoskeletal countermeasure during 5-day head-down tilt bed rest--results from the BRAG1 study.

Purpose: Human centrifugation, also called artificial gravity (AG), is proposed as a combined strategy against detrimental effects of microgravity in long-term space missions. This study scrutinized human short-arm centrifugation as countermeasure against musculoskeletal de-conditioning.

Method: Eleven healthy male subjects [mean age of 34 (SD 7) years] completed the cross-over trial, including three campaigns of -6° head-down tilt bed rest (HDT) for 5 days, with preceding baseline data collection and recovery phases.

Effects of an artificial gravity countermeasure on orthostatic tolerance, blood volumes and aerobic power after short-term bed rest (BR-AG1).

Exposure to artificial gravity (AG) in a short-arm centrifuge has potential benefits for maintaining human performance during long-term space missions. Eleven subjects were investigated during three campaigns of 5 days head-down bed rest: 1) bed rest without countermeasures (control), 2) bed rest and 30 min of AG (AG1) daily, and 3) bed rest and six periods of 5 min AG (AG2) daily. During centrifugation, the supine subjects were exposed to AG in the head-to-feet direction with 1 G at the center of mass.

Simultaneous scalp electroencephalography (EEG), electromyography (EMG), and whole-body segmental inertial recording for multi-modal neural decoding.

Recent studies support the involvement of supraspinal networks in control of bipedal human walking. Part of this evidence encompasses studies, including our previous work, demonstrating that gait kinematics and limb coordination during treadmill walking can be inferred from the scalp electroencephalogram (EEG) with reasonably high decoding accuracies. These results provide impetus for development of non-invasive brain-machine-interface (BMI) systems for use in restoration and/or augmentation of gait- a primary goal of rehabilitation research.

Sensorimotor posture control in the blind: superior ankle proprioceptive acuity does not compensate for vision loss.

To better understand sensorimotor posture control differences between blind and sighted individuals, we examined the role of ankle joint proprioception and ankle muscle strength on postural control in healthy blind (n=13, 25-58 years) and age- and sex-matched sighted (n=15, 20-65 years) volunteers. We measured ankle joint proprioceptive acuity and isokinetic muscle strength in plantarflexion and dorsiflexion using an isokinetic dynamometer. We also assessed postural control performance during quiet bipedal stance with and without sudden postural perturbations, and during quiet unipedal stance.

Posturography and locomotor tests of dynamic balance after long-duration spaceflight.

The currently approved objective clinical measure of standing balance in astronauts after space flight is the Sensory Organization Test battery of computerized dynamic posturography. No tests of walking balance are currently approved for standard clinical testing of astronauts. This study determined the sensitivity and specificity of standing and walking balance tests for astronauts before and after long-duration space flight.

Artificial gravity training reduces bed rest-induced cardiovascular deconditioning.

We studied 15 men (8 treatment, 7 control) before and after 21 days of 6º head-down tilt to determine whether daily, 1-h exposures to 1.0 G(z) (at the heart) artificial gravity (AG) would prevent bed rest-induced cardiovascular deconditioning. Testing included echocardiographic analysis of cardiac function, plasma volume (PV), aerobic power (VO(2)pk) and cardiovascular and neuroendocrine responses to 80º head-up tilt (HUT).

Estimating functional stability boundaries for bipedal stance.

We propose a technique to estimate functional limits of stability (LOS) during bipedal stance using a controlled, low speed, voluntary leaning protocol requiring feet to remain in contact with the ground. LOS are estimated from ellipses fit to center-of-mass position data obtained during the leaning protocol. The LOS of nine healthy subjects were found to be 20-59% closer to the center of stance than the more frequently used anatomical boundaries and were reduced by closing the eyes.

Diagnostic accuracy of dynamic posturography testing after short-duration spaceflight.

Introduction: Astronauts face transient disruptions of sensorimotor functions after spaceflight. Computerized dynamic posturography (CDP) testing has been used to document functional recovery; however, its objective value in return-to-duty decision-making has not been established. Therefore, we studied the diagnostic accuracy of CDP to determine the most effective test components for probing post-spaceflight sensorimotor deficits.