Publications by authors named "William H Mellick"
Article Synopsis
- The study reviews the last 25 years of functional magnetic resonance imaging drug cue reactivity (FDCR) research, highlighting the gap between findings and clinical applications as no FDCR-derived biomarkers have been approved yet.
- The objective is to summarize FDCR research, evaluate its readiness for biomarker development, and propose a systematic process for qualifying these biomarkers in the context of addiction treatment.
- Out of 415 published FDCR studies from 1998 to 2022, a significant number explored addictive substances like nicotine and alcohol, suggesting potential for developing various types of biomarkers related to addiction, though most studies mainly focused on therapeutic and diagnostic responses.
Importance: Reward circuitry dysfunction is a candidate mechanism of co-occurring bipolar disorder and alcohol use disorder (BD + AUD) that remains understudied. This functional magnetic resonance imaging (fMRI) research represents the first evaluation of alcohol cue reward processing in BD + AUD.
Objective: To determine how alcohol cue processing in individuals with BD + AUD may be distinct from that of individuals with AUD or BD alone.
Objective: Experiential avoidance (EA) is a transdiagnostic construct that may underlie the high comorbidity between major depressive disorder (MDD) and generalized anxiety disorder (GAD). This analysis used data from a longitudinal study (conducted September 2010-April 2016) to examine whether adolescent EA varies by MDD and GAD symptomatology trajectory and predicts said trajectories. Longitudinal associations between EA, anxiety, and depression symptoms were also examined.
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