Publications by authors named "William H Mellick"

Article Synopsis
  • The study reviews the last 25 years of functional magnetic resonance imaging drug cue reactivity (FDCR) research, highlighting the gap between findings and clinical applications as no FDCR-derived biomarkers have been approved yet.
  • The objective is to summarize FDCR research, evaluate its readiness for biomarker development, and propose a systematic process for qualifying these biomarkers in the context of addiction treatment.
  • Out of 415 published FDCR studies from 1998 to 2022, a significant number explored addictive substances like nicotine and alcohol, suggesting potential for developing various types of biomarkers related to addiction, though most studies mainly focused on therapeutic and diagnostic responses.
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Importance: Reward circuitry dysfunction is a candidate mechanism of co-occurring bipolar disorder and alcohol use disorder (BD + AUD) that remains understudied. This functional magnetic resonance imaging (fMRI) research represents the first evaluation of alcohol cue reward processing in BD + AUD.

Objective: To determine how alcohol cue processing in individuals with BD + AUD may be distinct from that of individuals with AUD or BD alone.

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Objective: Experiential avoidance (EA) is a transdiagnostic construct that may underlie the high comorbidity between major depressive disorder (MDD) and generalized anxiety disorder (GAD). This analysis used data from a longitudinal study (conducted September 2010-April 2016) to examine whether adolescent EA varies by MDD and GAD symptomatology trajectory and predicts said trajectories. Longitudinal associations between EA, anxiety, and depression symptoms were also examined.

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