Publications by authors named "William Gesztes"
Leptomeningeal metastasis (LMM) is a rare complication of non-small cell lung cancer (NSCLC) that can present with a range of neurological symptoms depending on the site(s) of metastatic involvement. We present a case of a 54-year-old woman who was initially diagnosed with suspected inflammatory neuritis secondary to a known systemic lupus erythematosus (SLE) diagnosis after presenting with multiple months of progressive neuro-ophthalmologic symptoms; however, she was eventually diagnosed with LMM secondary to a previously undiagnosed NSCLC. This case both underscores the challenges of diagnosing LMM due to its nonspecific presentation, as well as highlights the importance of including LMM in the differential diagnosis for patients presenting with vague neurological symptoms in the context of another inflammatory disease process.
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- - TP53 is a commonly mutated gene in prostate cancer, and assessing its focal alterations through immunohistochemistry (IHC) has improved the understanding of patient prognosis.
- - A study involving 189 prostate cancer patients showed that higher p53 expression and the presence of lymphovascular invasion (LVI) were tied to more advanced tumors and worse outcomes in terms of distant metastasis-free survival.
- - Targeted sequencing revealed that nearly 50% of tumors exhibited p53 expression, with seven out of ten sequenced showing TP53 mutations, reinforcing that elevated p53 levels are linked to potential negative changes in cancer progression.
Article Synopsis
- The study investigates the use of preoperative MRI and MRI-guided biopsy to predict biochemical recurrence (BCR) of prostate cancer after surgery.* -
- It found that specific MRI features, like a high PI-RADS score (5), larger index lesions, and signs of extraprostatic extension (EPE), are linked to shorter recurrence-free survival (RFS) in patients.* -
- The research indicates that suspicion of EPE at MRI and the intensity of p53 staining in biopsy samples could help stratify risk for postoperative BCR.*
Background: The relationship between race, prostate tumor location, and BCR-free survival is inconclusive. This study examined the independent and joint roles of patient race and tumor location on biochemical recurrence-free (BCR) survival.
Methods: A retrospective cohort study was conducted among men with newly diagnosed, biopsy-confirmed, NCCN-defined low risk CaP who underwent radical prostatectomy (RP) at the Walter Reed National Military Medical Center from 1996 to 2008.
Diagnostic and therapeutic recommendations of the actual guidelines regarding inflammatory bowel disease (IBD)-associated bone loss are based on the experiences from the general osteoporotic population. Moreover, the fracture, as an end point of the bone loss has a different relationship to the bone mineral density in these patients compared to the general population. In this review we aimed to review the literature of the novel therapeutic possibilities regarding IBD-related bone loss.
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