Publications by authors named "William Gao Peng"
J Am Heart Assoc
July 2024
Article Synopsis
- - ELMSAN1 is a newly identified protein essential for early heart development; studies on knockout mice show that lacking it leads to embryo death and heart defects, but its specific role in heart formation is not fully understood.
- - Researchers used human-induced pluripotent stem cells (hiPSCs) to investigate ELMSAN1’s function, finding that its depletion hinders proper differentiation into cardiac cells, reduces the expression of key cardiac markers, and results in immature cardiomyocytes with poor structural and functional properties.
- - This study highlights the critical role of ELMSAN1 in the maturation of hiPSC-derived cardiomyocytes, affecting aspects like cell development, sarcomere structure, calcium handling, and overall cardiac functionality.
