Publications by authors named "William G Peng"
Heart disease, particularly resulting from myocardial infarction (MI), continues to be a leading cause of mortality, largely due to the limited regenerative capacity of the human heart. Current therapeutic approaches seek to generate new cardiomyocytes from alternative sources. Direct cardiac reprogramming, which converts fibroblasts into induced cardiomyocytes (iCMs), offers a promising alternative by enabling in situ cardiac regeneration and minimizing tumorigenesis concerns.
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- - ELMSAN1 is a newly identified protein essential for early heart development; studies on knockout mice show that lacking it leads to embryo death and heart defects, but its specific role in heart formation is not fully understood.
- - Researchers used human-induced pluripotent stem cells (hiPSCs) to investigate ELMSAN1’s function, finding that its depletion hinders proper differentiation into cardiac cells, reduces the expression of key cardiac markers, and results in immature cardiomyocytes with poor structural and functional properties.
- - This study highlights the critical role of ELMSAN1 in the maturation of hiPSC-derived cardiomyocytes, affecting aspects like cell development, sarcomere structure, calcium handling, and overall cardiac functionality.