Publications by authors named "William Douglas Renton"
Article Synopsis
- Disabling pansclerotic morphea of childhood (DPMC) is a rare and aggressive form of juvenile localized scleroderma affecting primarily children under 14, leading to severe complications such as joint contractures and skin ulceration.
- Over a 29-month treatment period, a 5-year-old boy with refractory DPMC showed some improvement with prednisolone and mycophenolate mofetil (MMF), while other therapies like biologics and tyrosine kinase inhibitors proved ineffective, ultimately leading to a referral for a stem cell transplant.
- A literature review found that common treatments include methotrexate and corticosteroids, with MMF having anecdotal success; however, many patients end up needing intensive, multi-modal immun
