Publications by authors named "William Dankulich"
Article Synopsis
- LEDGF helps HIV integrate its DNA into the host genome by facilitating the action of HIV integrase, especially in areas that support viral gene expression.* -
- Allosteric integrase inhibitors (ALLINIs) target the LEDGF binding site on integrase and are more effective in blocking later stages of HIV replication than in preventing initial integration.* -
- A high-throughput screening identified new arylsulfonamide compounds that disrupt the IN-LEDGF interaction, leading to the development of a new class of ALLINIs with enhanced potency and a unique binding mechanism.*
A novel series of 16-substituted-4-azasteroids has been identified as potential tissue-selective androgen receptor modulators. These ligands display potent hAR binding and agonist activity, low virilizing potential, and good pharmacokinetic profiles in dogs. On the basis of its in vitro profile, 21 was evaluated in the OVX and ORX rat models and exhibited an osteoanabolic, tissue-selective profile.
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