Canine CNGA3 Gene Mutations Provide Novel Insights into Human Achromatopsia-Associated Channelopathies and Treatment.

Cyclic nucleotide-gated (CNG) ion channels are key mediators underlying signal transduction in retinal and olfactory receptors. Genetic defects in CNGA3 and CNGB3, encoding two structurally related subunits of cone CNG channels, lead to achromatopsia (ACHM). ACHM is a congenital, autosomal recessive retinal disorder that manifests by cone photoreceptor dysfunction, severely reduced visual acuity, impaired or complete color blindness and photophobia.

Measurement of plasma gentamicin concentrations postchemical ciliary body ablation in dogs with chronic glaucoma.

Objective: To investigate the absorption of gentamicin into the plasma after an intravitreal injection in dogs and to report the success rate of this procedure in lowering the intraocular pressure.

Animals: Twenty-four client-owned dogs with chronic, end-stage glaucoma.

Procedures: Dogs received a unilateral (22) or bilateral (2) intravitreal injection of 25-40 mg of gentamicin (mean ± SD dose 2.

Effects of oral administration of anti-inflammatory medications on inhibition of paracentesis-induced blood-aqueous barrier breakdown in clinically normal cats.

Objective: To assess inhibitory effects of orally administered anti-inflammatory medications on paracentesis-induced intraocular inflammation in clinically normal cats.

Animals: 30 clinically normal domestic shorthair cats.

Procedures: Cats were randomly assigned to a control group and 4 treatment groups.

Effects of ocular administration of ophthalmic 2% dorzolamide hydrochloride solution on aqueous humor flow rate and intraocular pressure in clinically normal cats.

Objective: To determine the effects of ocular administration of ophthalmic 2% dorzolamide hydrochloride solution on aqueous humor flow rate (AHFR) and intraocular pressure (IOP) in clinically normal cats.

Animals: 20 clinically normal domestic shorthair cats.

Procedures: Following an acclimation period, IOP was measured in each eye of all cats 5 times daily for 3 days to determine baseline values.

Evaluation of the aqueous humor flow rate in the eyes of clinically normal cats by use of fluorophotometry.

Objective: To evaluate aqueous humor flow rate in the eyes of clinically normal cats by use of a noninvasive technique successfully used in other species.

Animals: 20 domestic shorthair cats.

Procedures: 1 drop of 10% fluorescein sodium was instilled into both eyes of 5 cats every 5 minutes until 3 drops had been administered.

Ophthalmomyiasis externa in a puppy due to Cuterebra infestation.

An 8 wk old Scottish terrier was evaluated for a 2×2 cm mass located directly adjacent to the lateral canthus of the right eye. Examination revealed a well-developed Cuterebra larva at the lateral aspect of the orbital cavity, anchored at the lateral canthus. The larva was manually removed under general anesthesia, and the eyelid margin was repaired.

Ocular parameters in a captive colony of fruit bats.

Objectives: To establish normal reference ranges of ocular parameters including phenol read thread, palpebral fissure length, horizontal and vertical corneal diameter, upright and hanging intraocular pressure (IOP) and to report ophthalmic examination findings of the anterior segment and lens, in a population of captive fruit bats.

Animals Studied: Eyes of 30 bats of three species were included in this study: 10 (5 males, 5 females) Malayan Flying Foxes (Pteropus vampyrus), 10 (5 males, 5 females) Little Golden-mantled Flying Foxes (Pteropus pumilus), and 10 (4 males, 6 females) Island Flying Foxes (Pteropus hypomelanus).

Results: The most common ophthalmic examination findings included iris-iris persistent pupillary membranes (83%), nuclear sclerosis (56.

Relationship of the iridocorneal angle, as measured using ultrasound biomicroscopy, with post-operative increases in intraocular pressure post-phacoemulsification in dogs.

Objective: To investigate the relationship of the iridocorneal angle as it appears on ultrasound biomicroscopy (UBM) to increases in IOP post-phacoemulsification in the canine eye. Animals studied 47 eyes of 28 dogs of various age, sex, and breed.

Methods: The ciliary process and limbus were used as a reference points to measure the angle opening distance (AOD), which was set by multiplying 0.