Publications by authors named "William Connolly"
The increasing prevalence of multi-drug resistant pathogens has led to a renewed focus on the use of silver as an antibiotic-independent antimicrobial. Unfortunately, the use of many silver formulations may be limited by an uncontrolled release of silver with the potential for significant cytotoxic effects. Silver carboxylate (AgCar) has emerged as an alternative formulation of silver with the potential to mitigate these concerns while still displaying significant bactericidal activity.
View Article and Find Full Text PDFVancomycin-resistant and multi-drug-resistant (MDR) are rising contributors to spinal fusion and fracture-associated infections (FAI), respectively. These MDR bacteria can form protective biofilms, complicating traditional antibiotic treatment. This study explores the effects of the antibiotic-independent antimicrobial silver carboxylate (AgCar)-doped coating on the adherence sand proliferation of these pathogens on orthopedic implant materials utilized in spinal fusion and orthopedic trauma fixation.
View Article and Find Full Text PDFArticle Synopsis
- - The rise of multi-drug-resistant organisms has led to renewed interest in silver as a safer alternative to traditional antibiotics, given its lower risk for developing bacterial resistance and its various modes of action.
- - Despite its antimicrobial benefits, high concentrations of silver can be toxic, prompting research into new formulations that ensure safer and more predictable use in clinical settings.
- - A thorough review of different silver formulations highlighted their mechanisms, clinical applications, and toxicity risks, identifying a trend where newer formulations may offer better clinical potential, but further in vivo studies are needed to confirm their effectiveness.