Publications by authors named "William C. Baker"
Background Colorectal cancer most commonly affects the elderly population. Post-colorectal cancer surveillance aims to reduce cancer incidence and mortality, but its necessity and effectiveness are debated, especially in the elderly population. This study explores the relevance of computer tomography (CT) and colonoscopy surveillance in patients aged 75 and over who have undergone curative resection for colorectal cancer.
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- - This study explores how neoadjuvant therapy (NAT) impacts skeletal muscle mass, myosteatosis, and fitness in patients with oesophago-gastric cancer, highlighting that all these factors are linked to postoperative outcomes.
- - Among 184 patients, significant decreases in muscle mass, radiation-attenuation, and fitness were observed after NAT; however, only the pectoralis muscle mass effectively correlated with peak exercise performance.
- - The findings indicate that while sarcopenia and myosteatosis didn't impact morbidity or survival, better cardiorespiratory fitness (measured through CPET) is crucial for improving short-term survival post-surgery.
The facile, high-yielding synthesis of a series of macrocycles 7a-k in 75-100% yield is reported. The transformation of these compounds to their carboxymethylated analogues 8a-k in 75-90% yield and subsequent gadolinium complexes 9a-k provides a series of homologous neutral paramagnetic contrast agents (PCAs) with tunable lipophilicity. Alkylated cationic intermediates 6a-k are prepared in yields of 72-94% from glyoxal adduct of cyclen (5) and slight excesses of alkyl iodides.
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