Adaptive biohybrid pumping machine with flow loop feedback.

Tissue-engineered living machines is an emerging discipline that employs complex interactions between living cells and engineered scaffolds to self-assemble biohybrid systems for diverse scientific research and technological applications. Here, we report an adaptive, autonomous biohybrid pumping machine with flow loop feedback powered by engineered living muscles. The tissue is made from skeletal muscle cells (C2C12) and collagen I/Matrigel matrix, which self-assembles into a ring that compresses a soft hydrogel tube connected at both ends to a rigid fluidic platform.

Fabrication of cell penetrating peptide-conjugated bacterial cellulose nanofibrils with remarkable skin adhesion and water retention performance.

Bacterial cellulose nanofibrils (BCNFs), possessing excellent biocompatibility as well as hygroscopicity, are receiving high interest as a biomaterial for biomedical and healthcare treatments, since they exert various interactions with tissues after surface modification with biochemicals such as peptides, proteins, and catechols. Herein, we report a BCNF-based skin adhesion system, wherein cell penetrating peptide (CPP)-conjugated BCNFs were employed to enhance the attraction to the skin under wet conditions. For this, we conjugated Bac7, a type of CPP, with the carboxylate of 2,2,6,6-tetramethylpiperidine-1-oxyl radical (TEMPO)-oxidized BCNFs.