Early antiretroviral therapy in SIV-infected rhesus macaques reveals a multiphasic, saturable dynamic accumulation of the rebound competent viral reservoir.

The rebound competent viral reservoir (RCVR)-virus that persists during antiretroviral treatment (ART) and can reignite systemic infection when treatment is stopped-is the primary barrier to eradicating HIV. We used time to initiation of ART during primary infection of rhesus macaques (RMs) after intravenous challenge with barcoded SIVmac239 as a means to elucidate the dynamics of RCVR establishment in groups of RMs by creating a multi-log range of pre-ART viral loads and then assessed viral time-to-rebound and reactivation rates resulting from the discontinuation of ART after one year. RMs started on ART on days 3, 4, 5, 6, 7, 9 or 12 post-infection showed a nearly 10-fold difference in pre-ART viral measurements for successive ART-initiation timepoints.

Rapamycin limits CD4+ T cell proliferation in simian immunodeficiency virus-infected rhesus macaques on antiretroviral therapy.

Proliferation of latently infected CD4+ T cells with replication-competent proviruses is an important mechanism contributing to HIV persistence during antiretroviral therapy (ART). One approach to targeting this latent cell expansion is to inhibit mTOR, a regulatory kinase involved with cell growth, metabolism, and proliferation. Here, we determined the effects of chronic mTOR inhibition with rapamycin with or without T cell activation in SIV-infected rhesus macaques (RMs) on ART.

Electrochemical impedance spectroscopy study of corrosion characteristics of palladium-silver dental alloys.

Electrochemical impedance spectroscopy (EIS) has been used to obtain insight into corrosion processes for three Pd-Ag alloys, and compare their behavior with an Au-Pd alloy. Five specimens of each alloy received clinically-appropriate simulated porcelain-firing heat treatment. EIS testing was performed at ambient temperature, using 0.

ICP-MS measurements of elemental release from two palladium alloys into a corrosion testing medium for different solution volumes and agitation conditions.

Statement Of Problem: The in vivo release of Pd from palladium alloys into the oral environment and sensitivity reactions by patients has been of concern. However, little information is available about the variation in elemental release from different palladium alloys.

Purpose: The purpose of this in vitro study was to compare the elemental release into a corrosion-testing medium from a high-palladium alloy (Freedom Plus, 78Pd-8Cu-5Ga-6In-2Au) and a Pd-Ag alloy (Super Star, 60Pd-28Ag-6In-5Sn) under different conditions.

Evaluating a New Class of AKT/mTOR Activators for HIV Latency Reversing Activity .

An ability to activate latent HIV-1 expression could benefit many HIV cure strategies, but the first generation of latency reversing agents (LRAs) has proven disappointing. We evaluated AKT/mTOR activators as a potential new class of LRAs. Two glycogen synthase kinase-3 inhibitors (GSK-3i's), SB-216763 and tideglusib (the latter already in phase II clinical trials) that activate AKT/mTOR signaling were tested.

Evolution, clinical applications, and prospects of nickel-titanium alloys for orthodontic purposes.

This review article presents an evolution of the nickel-titanium wires for orthodontics, following their introduction by the pioneering studies of Andreasen. The original nonsuperelastic wires were followed by the introduction of superelastic Japanese NiTi wire by Miura and colleagues and Chinese NiTi wire by Burstone and colleagues. Subsequently, new nickel-titanium wires with true shape memory in the oral environment were introduced.

Fracture analysis of monolithic CAD-CAM crowns.

Purpose: The aim of this study was to compare the integrity of zirconia, lithium disilicate, and zirconia-reinforced lithium silicate CAD-CAM crowns after being subjected to cyclic loading and then subjected to static loading until fracture.

Material And Methods: Zirconia (Zirkonzahn), lithium disilicate (LDS, Ivoclar Vivadent AG), and zirconia-reinforced lithium silicate glass ceramic (ZLS) (Vita Suprinity, Vita Zahnfabrik) monolithic crowns were milled (n = 6). The crowns were bonded using composite resin cements and subjected to cyclic loading under wet conditions.

Potentiodynamic polarization study of the corrosion behavior of palladium-silver dental alloys.

Statement Of Problem: Although palladium-silver alloys have been marketed for over 3 decades for metal-ceramic restorations, understanding of the corrosion behavior of current alloys is incomplete; this understanding is critical for evaluating biocompatibility and clinical performance.

Purpose: The purpose of this in vitro study was to characterize the corrosion behavior of 3 representative Pd-Ag alloys in simulated body fluid and oral environments and to compare them with a high-noble Au-Pd alloy. The study obtained values of important electrochemical corrosion parameters, with clinical relevance, for the rational selection of casting alloys.

In vitro fit of CAD-CAM complete arch screw-retained titanium and zirconia implant prostheses fabricated on 4 implants.

Statement Of Problem: Computer-aided designed and computer-aided manufactured (CAD-CAM) titanium and zirconia implant-supported fixed implant prostheses on 4 implants have become popular. The precision and accuracy of their interface fit has not been widely researched.

Purpose: The purpose of this in vitro study was to compare the marginal fit of zirconia and titanium implant-supported screw-retained CAD-CAM complete fixed dental prostheses (CFDP) fit with a standardized cast simulating the all-on-4 implant distribution.

A load-to-fracture and strain analysis of monolithic zirconia cantilevered frameworks.

Statement Of Problem: The dimensions of implant-supported fixed cantilevered prostheses are important to prevent mechanical and biological complications. Information on the optimum thickness and cantilever length for improving the strength of zirconia cantilevered frameworks is limited in the literature.

Purpose: The purpose of this in vitro study was to investigate the effect of cantilever length and occlusocervical thickness on the load-to-fracture and strain distribution of zirconia frameworks.

Comparison of 3D displacements of screw-retained zirconia implant crowns into implants with different internal connections with respect to screw tightening.

Statement Of Problem: Internal conical implant-abutment connections without horizontal platforms may lead to crown displacement during screw tightening and torque application. This displacement may affect the proximal contacts and occlusion of the definitive prosthesis.

Purpose: The purpose of this in vitro study was to evaluate the displacement of custom screw-retained zirconia single crowns into a recently introduced internal conical seal implant-abutment connection in 3D during hand and torque driver screw tightening.

Distortion of CAD-CAM-fabricated implant-fixed titanium and zirconia complete dental prosthesis frameworks.

Statement Of Problem: Computer-aided design and computer-aided manufacturing (CAD-CAM)-fabricated titanium and zirconia implant-supported fixed dental prostheses have become increasingly popular for restoring patients with complete edentulism. However, the distortion level of these frameworks is not well known.

Purpose: The purpose of this in vitro study was to compare the 3-dimensional (3D) distortion of CAD-CAM zirconia and titanium implant-fixed screw-retained complete dental prostheses.

Wear characteristics and inhibition of enamel demineralization by resin-based coating materials.

In this study, wear and inhibition of enamel demineralization by resin-based coating materials were investigated. Seven commercially available coating materials, with and without fillers, were used. A mechanical wear test was performed, and the specimens were then examined with a scanning electron microscope.

Differences between buccal and lingual bone quality and quantity of peri-implant regions.

The objective of the current study was to examine whether peri-implant bone tissue properties are different between the buccal and lingual regions treated by growth factors. Four dental implant groups were used: titanium (Ti) implants, alumina-blasted zirconia implants (ATZ-N), alumina-blasted zirconia implants with demineralized bone matrix (DBM) (ATZ-D), and alumina-blasted zirconia implants with rhBMP-2 (ATZ-B). These implants were placed in mandibles of six male dogs.

Hydroxyapatite precipitation on nanotube surfaces of Ti-35Ta-xNb alloys.

Hydroxyapatite precipitation on nanotube surfaces of Ti-35Ta-xNb alloys was investigated using electrochemical methods. The alloys were prepared by arc-melting, heat treated at 1050 degrees C for 12 h in an Ar atmosphere, and quenched in 0 degrees C water. Nanotubes were created on the Ti-35Ta-xNb alloys in a 1 M H3PO4 + 1.

Nanotube nucleation phenomena on Ti-25Ta-xZr alloys for implants using ATO technique.

The purpose of this study was to investigate nanotube nucleation phenomena on the Ti-25Ta-xZr alloys for implant materials, using an anodic titanium oxide (ATO) technique. Ti-25Ta-(0 wt.%-15 wt.

Effects of quaternary ammonium-methacrylates on the mechanical properties of unfilled resins.

Objective: Adding antimicrobial/anti-MMP quaternary ammonium methacrylates (QAMs) to comonomer blends should not weaken the mechanical properties of dental resins. This work evaluated the degree conversion and mechanical properties of BisGMA/TEGDMA/HEMA (60:30:10) containing 0-15 mass% QAMs A-E (A: 2-acryloxyethyltrimethyl ammonium chloride; B: [3-(methacryloylamino)propyl]trimethylammonium chloride; C: [2-(methacryloxy)ethyl] trimethyl ammonium chloride; D: diallyldimethyl ammonium chloride; E: 2-(methacryloyloxy) ethyltrimethyl ammonium methyl sulfate.

Methods: Unfilled resins with and without QAM were placed on ATR-FTIR and light-polymerized for 20s in a thin film at 30°C.

Comparison of the metal-to-ceramic bond strengths of four noble alloys with press-on-metal and conventional porcelain layering techniques.

Statement Of Problem: New noble alloys for metal ceramic restorations introduced by manufacturers are generally lower-cost alternatives to traditional higher-gold alloys. Information about the metal-to-ceramic bond strength for these alloys, which is needed for rational clinical selection, is often lacking.

Purpose: The purpose of this study was to evaluate the bond strength of 4 recently introduced noble alloys by using 2 techniques for porcelain application.

Effects of third-order torque on frictional force of self-ligating brackets.

Objective: To investigate the effects of third-order torque on frictional properties of self-ligating brackets (SLBs).

Materials And Methods: Three SLBs (two passive and one active) and three archwires (0.016 × 0.

Optical characteristics of contemporary dental composite resin materials.

Objectives: Optical and physical properties of dental restorative composite materials are affected by composition. Basic optical absorption and scattering properties have been derived through the use of a corrected reflectance model, but practical and important optical properties are not easily derived from these basic spectral characteristics. The purposes of this study are to derive and compare colour and translucency characteristics of two cured contemporary nanohybrid composites being marketed as universal composites, and to evaluate colour difference between each composite material and published shade guide data.

Effects of mechanical properties of thermoplastic materials on the initial force of thermoplastic appliances.

Objective: To measure the forces delivered by thermoplastic appliances made from three materials and investigate effects of mechanical properties, material thickness, and amount of activation on orthodontic forces.

Materials And Methods: Three thermoplastic materials, Duran (Scheu Dental), Erkodur (Erkodent Erich Kopp GmbH), and Hardcast (Scheu Dental), with two different thicknesses were selected. Values of elastic modulus and hardness were obtained from nanoindentation measurements at 28°C.

Viscoelastic properties of elastomeric chains: an investigation of pigment and manufacturing effects.

Introduction: Orthodontic elastomeric chains are commercially available in various colors from many manufacturers. In this study, we investigated the viscoelastic properties of elastomeric chains using dynamic mechanical analysis to perform color and brand comparisons.

Methods: Ten colors of Sunburst chains (GAC International, Bohemia, NY) were selected for the color study.

Biocompatibility of dental amalgams.

Objective. The purpose of this review paper is to review the literature regarding the toxicology of mercury from dental amalgam and evaluate current statements on dental amalgam. Materials and Methods.

Frictional and mechanical properties of diamond-like carbon-coated orthodontic brackets.

This study investigated the effects of a diamond-like carbon (DLC) coating on frictional and mechanical properties of orthodontic brackets. DLC films were deposited on stainless steel brackets using the plasma-based ion implantation/deposition (PBIID) method under two different atmospheric conditions. As-received metal brackets served as the control.