Synopsis of recent research by authors named "William Bourn"
- William Bourn's research primarily focuses on developing innovative vaccine vectors, particularly using recombinant strains of Mycobacterium bovis BCG and Salmonella enterica, to elicit immune responses against HIV-1 and other pathogens.
- His studies demonstrate that BCG can be engineered to express HIV-1 antigens, although challenges in genetic stability and immunogenicity persist; however, these engineered strains can effectively prime immune responses when boosted with virus-like particles.
- Bourn has also contributed to the advancement of plasmid vectors in mycobacteria for gene delivery, showcasing their potential as DNA vaccine carriers by enhancing immune system targeting and response in various animal models.
