Publications by authors named "William B McGuire"
The Kaiser Permanente (KP) Research Program on Genes, Environment and Health (RPGEH), in collaboration with the University of California-San Francisco, undertook genome-wide genotyping of >100,000 subjects that constitute the Genetic Epidemiology Research on Adult Health and Aging (GERA) cohort. The project, which generated >70 billion genotypes, represents the first large-scale use of the Affymetrix Axiom Genotyping Solution. Because genotyping took place over a short 14-month period, creating a near-real-time analysis pipeline for experimental assay quality control and final optimized analyses was critical.
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- * Out of 106,902 samples tested, 98.7% passed quality control, revealing that telomere length typically declines with age up to 75, but interestingly, individuals over 75 showed a positive correlation between age and longer telomeres, suggesting improved longevity.
- * The research found that women generally have longer telomeres than men, significant in those over 50, and it noted increased variability in telomere length with age, reinforcing