Publications by authors named "William A Molina Arocho"
Proliferating tumor cells take up glutamine for anabolic processes, engendering glutamine deficiency in the tumor microenvironment. How this might impact immune cells is not well understood. Using multiple mouse models of soft tissue sarcomas, glutamine antagonists, as well as genetic and pharmacological inhibition of glutamine utilization, we found that the number and frequency of conventional dendritic cells (cDCs) is dependent on microenvironmental glutamine levels.
View Article and Find Full Text PDFArticle Synopsis
- A new subset of macrophages called iron-rich tumor-associated macrophages (iTAMs) was identified, marked by high levels of intracellular iron and involvement in angiogenesis and immunosuppression in tumors.
- Two types of iTAMs were characterized based on their location and gene expression: perivascular (pviTAM) and stromal (stiTAM).
- The endothelin receptor type B (Ednrb) was identified as a specific marker for iTAMs, and its deletion reduced tumor growth, while the transcription factor Bach1 was found to regulate iTAM functions by inhibiting Ednrb expression.
Unlabelled: Proliferating tumor cells take up glutamine for anabolic processes engendering glutamine deficiency in the tumor microenvironment. How this might impact immune cells is not well understood. Using multiple mouse models of soft tissue sarcomas, glutamine antagonists, as well as genetic and pharmacological inhibition of glutamine utilization, we found that the number and frequency of conventional dendritic cells (cDC) is dependent on microenvironmental glutamine levels.
View Article and Find Full Text PDFGlobally, hepatocellular carcinoma (HCC) is one of the most commonly diagnosed cancers and a leading cause of cancer-related death. We previously identified an immune evasion pathway whereby tumor cells produce retinoic acid (RA) to promote differentiation of intratumoral monocytes into protumor macrophages. Retinaldehyde dehydrogenase 1 (RALDH1), RALDH2, and RALDH3 are the three isozymes that catalyze RA biosynthesis.
View Article and Find Full Text PDF