Perioral wrinkles: histologic differences between men and women.

Background: Women tend to develop more and deeper wrinkles in the perioral region than men. Although much is known about the complex mechanisms involved in skin aging, previous studies have described histologic differences between men and women with respect to skin aging only incidentally and have not investigated the perioral region.

Objective: The purpose of this study was to investigate gender-specific differences in the perioral skin.