Publications by authors named "Willem Does"

It has been proposed that maximizing expectancy violation enhances the efficacy of exposure therapy. The clinical utility of expectancy violation remains unclear and it has not yet been studied in PTSD. We aimed to test whether explicitly focusing on expectancy violation leads to superior exposure outcomes.

View Article and Find Full Text PDF

Eveningness has been associated with both disturbed sleep and depression. It is unclear, however, if deprived sleep explains evening types' vulnerability to depression. The role of pre-sleep rumination in these associations also remains understudied.

View Article and Find Full Text PDF

Objectives: Working alliance is considered an important determinant of outcome of psychotherapy. Patients with posttraumatic stress disorder (PTSD) following childhood abuse (CA-PTSD) may have challenges in building interpersonal relationships, including working alliance. Phase-based treatment provides an opportunity to strengthen alliance prior to trauma-focused treatment.

View Article and Find Full Text PDF

Background And Objectives: Inhibitory Learning Theory (ILT) framework implies that in-session distress variability may promote extinction learning and thereby enhance exposure therapy efficacy. Thus far, research has mainly focused on in-session distress reduction. The aim of the current study was to assess whether in-session distress variability predicts next session PTSD symptom decline in PTSD patients receiving prolonged exposure (PE).

View Article and Find Full Text PDF

Parental verbal threat (vs. safety) information about strangers may induce fears of these strangers in adolescents. In this multi-method experimental study, utilizing a within-subject design, parents provided standardized verbal threat or safety information to their offspring (N = 77, M = 11.

View Article and Find Full Text PDF

Children can acquire fears of novel stimuli as a result of listening to parental verbal threat information about these stimuli (i.e., instructional learning).

View Article and Find Full Text PDF

Recent studies indicated that Prolonged Exposure (PE) is safe and effective for posttraumatic stress disorder (PTSD). It is unclear whether PE also leads to a reduction in comorbid diagnoses. Data from a large randomized controlled trial ( = 149) on the effects of three variants of PE for PTSD were used.

View Article and Find Full Text PDF

Infants can acquire fears vicariously by observing parents' fearful reactions to novel stimuli in everyday situations (i.e., modeling).

View Article and Find Full Text PDF

Prolonged exposure (PE) is an effective treatment for post-traumatic stress disorder (PTSD). This study aimed to analyse the cost-effectiveness of three exposure-based treatments in patients with childhood abuse-related PTSD. A net-benefit analysis was conducted alongside a pragmatic randomized controlled trial with participants (= 149) randomized to three conditions: PE (48), intensified PE (i-PE, = 51), and phase-based PE [Skills Training in Affective and Interpersonal Regulation (STAIR) + PE, = 50].

View Article and Find Full Text PDF
Article Synopsis
  • The study investigates how changes in negative posttraumatic cognitions may help reduce PTSD symptoms in patients undergoing Prolonged Exposure (PE) therapy, particularly those with a history of childhood abuse.
  • By analyzing data from 83 patients at different treatment stages, the research shows that improvements in posttraumatic cognitions predict subsequent decreases in PTSD symptoms, rather than the other way around.
  • The findings support the idea that addressing negative cognitions is crucial in PE therapy and suggest using the abbreviated Posttraumatic Cognitions Inventory (PTCI-9) to monitor these cognitive changes over time.
View Article and Find Full Text PDF

Introduction: Theoretical and empirical evidence suggests that the effect of parental verbal threat information on the offspring's fear acquisition of novel stimuli may be causal. The current study investigated this verbal fear acquisition pathway from parents to children in the unique context of Covid-19 as a novel environmental threat for parents and children.

Methods: Using an online cross-sectional survey, we collected data about fear of Covid-19, parent-child communication, parental anxiety, and child temperament, in the period between June 11th 2020 and May 28th 2021.

View Article and Find Full Text PDF

There is growing evidence that change in distress is an indicator of change during Prolonged Exposure (PE) for posttraumatic stress disorder (PTSD). However, temporal sequencing studies investigating whether change in distress precedes PTSD symptom decline are lacking. These studies are essential since the timeline between indicators of change and treatment outcome is a key assumption for mediation.

View Article and Find Full Text PDF

Background: The Netherlands Study of Depression and Anxiety (NESDA; N=2981) is an ongoing longitudinal, multi-site, naturalistic, cohort study examining the etiology, course, and consequences of depression and anxiety. In this article we synthesize and evaluate fifteen years of NESDA research on prominent psychological risk factors for the onset, persistence, recurrence, and comorbidity of affective disorders.

Methods: A narrative review of 62 NESDA articles examining the specificity and predictive value of neuroticism, behavioral inhibition, repetitive negative thinking, experiential avoidance, cognitive reactivity, locus of control, (implicit) self-esteem, (implicit) disorder-specific self-associations, and attentional bias for the course of affective disorders.

View Article and Find Full Text PDF

Background: Differences in effectiveness among treatments for posttraumatic stress disorder (PTSD) are typically small. Given the variation between patients in treatment response, personalization offers a new way to improve treatment outcomes. The aim of this study was to identify predictors of psychotherapy outcome in PTSD and to combine these into a personalized advantage index (PAI).

View Article and Find Full Text PDF
Article Synopsis
  • Evidence-based treatments for PTSD may not perform as well for patients with Complex-PTSD (CA-PTSD), prompting a study to compare three versions of prolonged exposure therapy.
  • 149 adults with CA-PTSD were randomly assigned to one of three treatment groups: standard Prolonged Exposure, intensified Prolonged Exposure, or a phase-based approach combining skills training with exposure therapy.
  • All treatments showed significant improvements in PTSD symptoms over time, with intensified treatments leading to quicker symptom reductions initially, but no substantial differences in long-term effectiveness among the groups.
View Article and Find Full Text PDF
Article Synopsis
  • - The study examined how Complex Posttraumatic Stress Disorder (CPTSD) affects treatment outcomes for various therapies aimed at addressing PTSD, specifically targeting childhood abuse-related cases.
  • - Over half of the 149 patients studied were found to have CPTSD, which correlated with more severe symptoms and additional mental health issues at the start, but it did not predict or influence the effectiveness of treatment methods.
  • - The research highlights that while CPTSD is associated with greater symptom severity and comorbidity, it does not determine how well a patient responds to different PTSD treatments, suggesting that more research with diverse samples is necessary.
View Article and Find Full Text PDF

Background: The recommendations of experts who write review articles are a critical determinant of the adaptation of new treatments by clinicians. Several types of reviews exist (narrative, systematic, meta-analytic), and some of these are more vulnerable to researcher bias than others. Recently, the interest in nutritional interventions in psychiatry has increased and many experts, who are often active researchers on this topic, have come to strong conclusions about the benefits of a healthy diet on depression.

View Article and Find Full Text PDF

A growing number of studies suggest that EEG theta/beta ratio (TBR) is inversely related to executive cognitive control. Neurofeedback training aimed at reducing TBR (TBR NFT) might provide a tool to study causality in this relation and might enhance human performance. To investigate whether TBR NFT reduces TBR in healthy participants.

View Article and Find Full Text PDF

Background: Signs and symptoms of psychopathology can be chronic but are generally regarded as less stable over time than markers of cognitive vulnerability and personality. Some findings suggest that these differences in temporal stability are modest in size but a rigorous examination across concepts is lacking. The current study investigated the temporal stability of affective symptoms, cognitive vulnerability markers and personality traits at various assessments over nine years.

View Article and Find Full Text PDF

The ratio between frontal resting-state electroencephalography (EEG) theta and beta frequency power (theta/beta ratio, TBR) is negatively related to cognitive control. It is unknown which psychological processes during resting state account for this. Increased theta and reduced beta power are observed during mind wandering (MW), and MW is related to decreased connectivity in the executive control network (ECN) and increased connectivity in the default mode network (DMN).

View Article and Find Full Text PDF